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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. An Intraoperative Guidance Platform for Radio Frequency Ablation

    SBC: NE Scientific, LLC            Topic: 102

    Project Summary: The objective of this proposed research program is to develop a platform for planning and guidance during Radio Frequency Ablation (RFA). RFA is a thermally mediated ablation technique, where an applicator carrying one electrode is inserted into tumors percutaneously (or via laparoscopy, or open surgical approaches). Radio Frequency (RF) energy is applied, denaturating and coagula ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Marketing Strategic Plan and Distribution Logistics for Sanaria PfSPZ Vaccine against Malaria.

    SBC: SANARIA INC.            Topic: NIAID

    ABSTRACT The development of Sanaria s Plasmodium falciparumPfsporozoiteSPZbased vaccines is receiving overwhelming global support after the publication inin Science of clinical data showingprotection against controlled human malaria infectionCHMIfollowing intravenous administration ofdoses of SanariaPfSPZ Vaccinecomposed of purifiedasepticradiation attenuatedcryopreserved PfSPZ meeting all regulat ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Improved long-term biocompatibility of coronary stents by plasma coating process

    SBC: NANOVA INC.            Topic: NHLBI

    Improved long term biocompatibility of coronary stents by plasma coating process Abstract Drug eluting stentsDEShave been widely used to treat patients of coronary heart diseaseCHDdue to their better ability to control restenosis than bare metal stentsBMSHoweverthere is a high risk of late in stent thrombosis associated with DES after implantation in patientswhich could lead to fatal heart attack ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Antithrombotic Therapy with No Bleeding Risk for PCI

    SBC: APT THERAPEUTICS, INC.            Topic: y

    Adjunctive antithrombotic treatment with dual antiplatelet therapyaspirinP Yantagonistplus anticoagulantheparin or bivalirudinis a guideline mandated for percutaneous coronaryinterventionPCIpatientsDespite aggressive antithrombotic therapyhowevermyocardialperfusion after PCI remains inadequate in many patientsReocclusion from recurrent thrombosiscontinues to occurand dose limiting bleeding occurs ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Validation of an In Vitro Human Airway Model for Regulatory Toxicity Testing

    SBC: Mattek Corporation            Topic: NIEHS

    Results of Phase II research indicate that formal validation of the EpiAirwayin vitro human bronchial tissue model for predicting toxicity of inhaled chemicals is an attainable goalThe proposed Phase IIB cooperative agreement project is intended to realize this goal by conducting formal ring trial validation studies that will be submitted to regulatory agencies and the Organization for Economic Co ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Novel non-invasive antigen detection assay for the diagnosis of active visceral leishmaniasis and to monitor the therapy efficacy of this disease

    SBC: DETECTOGEN INC.            Topic: NIAID

    ABSTRACTThe overall goal of this Phase II project is to validate novel leishmanial protein biomarkers for development of a non invasive urine based assay to diagnose active visceral leishmaniasisVLand to monitor the therapeutic efficacy of this serious diseaseVL is endemic incountriesaffectspeople a year and kills more thanof them children under ageVLalso known as kala azaris caused by parasites o ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. OnTrack> An Online Role-Playing Game

    SBC: C4 Innovations, LLC            Topic: 104

    Project Summary First episode psychosis is a serious mental health condition that affects youth and young adultsoften between the ages ofandThe illness is marked by hallucinationsdelusionswithdrawalpoor organization skillsand diminished cognitive and social functioningRecent research has demonstrated that programs designed to treat people experiencing early psychosis can reduce hospitalizationdecr ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Evidence-Based Pain Intervention for Veterans: Leveraging Mobile and Social Media

    SBC: Pro-Change Behavior Systems Inc            Topic: NCCIH

    Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. AVGN7, a Novel Gene Therapeutic for Treating Cancer Cachexia

    SBC: Aavogen, Inc.            Topic: 102

    PROJECT SUMMARYThe skeletal muscle wasting that occurs with cancer cachexia compromises quality of life and is both directly and indirectly responsible for cancer mortalitiesTumor derived and tumor responsive factors as well as many therapeutics themselves contribute to the cachectic statealthough nutritional support has little if any positive effect on restoring striated muscle mass or functionTh ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Next Generation Western for high-throughput and high-content protein analysis

    SBC: LI-COR, Inc.            Topic: 400

    Abstract The identification and quantification of specific proteins in complex samples are critical processes in discoveringunderstandingand ultimately addressingthe underlying nature of human health and diseaseThe western blot is a fundamental method used for these processes due to the sensitivity and specificity enabled by combining protein sizing with immuno detectionDespite being widelyusedthe ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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