Award Data

FEASIBILITY IS EXAMINED FOR A HAND-HELD INSTRUMENT TO MEASURE THRUST FORCE AND JOINT MOTION DURING SPINAL MANIPULATION AND REHABILITATION OF PATIENTS WITH NEUROMUSCULAR APPLICATION TO THE HEALTH FIELD: PROVIDE NONINVASIVE MONITORING AND CONTROL OF FORCES APPLIED DURING PHYSICAL REHABILITATION PROCEDURES FOR THE BACK. THIS INSTRUMENTATION IS EXPECTED TO PROMOTE PATIENT SAFETY, ESPECIALLY THOSE AT R ...

THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID ADDUCTS CLASSIFIED AS METHYLFURYLBUTYROLACTONES, ALSO REFERRED TO AS NAFOCARE B. WORKING IN COLLABORATION WITH A SYNTHETIC ORGANIC CHEMISTRY GROUP AT WEST VIRGINIA UNIVERSITY, WE HAVE DETERMINED THAT THE PARENT COMPOUND, MFBL, HAS EXTENSIVE IMMUNE POTENTIATING ACTIVITY. OUR PROJECT WILL ANALYZE FIVE NEW DERIVATIVES OF L- ...

AND ITS POTENTIAL APPLICATION TO HUMAN HYBRIDOMA TECHNOLOGY.THIS PROJECT INVOLVES DETERMINING THE ABILITY OF A NEW CLASS OF SYNTHETIC BIOLOGICAL RESPONSE MODIFIERS (BRM) KNOWN AS METHYLFURYLBUTYROLACTONES (MFBL) TO AUGMENT THE PRODUCTION OF LYMPHOKINES (IL-2, B-CELL GROWTH FACTOR, AND IMMUNE INTERFERON) AND MONOKINES (IL-1, PROSTAGLANDINS, AND CYTOLYTIC FACTOR). OUR LABORATORY HAS DETERMINED THAT ...

ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY. DATA ACCUMULATED BY OUR LABORATORIES INDICATE THAT THE METHYLFURYLBUTYROLACTONE (MFBL) CLASS OF COMPOUNDS REPRESENTS NEW SYNTHETIC IMMUNE RESPONSE MODIFIERS CAPABLE OF ACTIVATING SEVERAL COMPONENTS OF IMMUNE RESPONSE WITH NEGLIGIBLE T ...

THE OBJECTIVE OF THIS STUDY IS TO PREPARE ANTINEOPLASTIC PLATINUM COMPLEXES WITH STABILITIES IN SOLUTION GREATER THANTHAT OF 4-CARBOXYPHTHALATO(1,2-DIAMINOCYCLOHEXANE) PLATINUM (NSC 271674;DACHPT). NSC 271674 IS A CISPLATIN ANALOG INVENTED BY THE APPLICANT AND NOW IN PHASE II CLINICAL TRIALS AT MEMORIAL SLOAN-KETTERING CANCER CENTER IN NEW YORK. IT IS ACTIVE AGAINST CISPLATIN-RESISTANT TUMORS WITH ...

THE PROVEN CLINICAL EFFECTIVENESS OF CISPLATIN AS WELL AS SEVERAL SECOND GENERATION ANALOGS HAS ESTABLISHED THE ROLE OF METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY. COMPLEXES OF METALS OTHER THAN PLATINUM HAVE BEEN OFTEN POORLY DESIGNED BECAUSE THEY WERE MODELED AFTER THE ACTIVE PLATINUM COMPLEXES WITHOUT CONSIDERING THEIR DIFFERENT THERMODYNAMIC AND KINETIC PARAMETERS. IN PARTICULAR, PALL ...

THE OBJECTIVE OF THIS STUDY IS TO SYNTHESIZE, CHARACTERIZE, AND EVALUATE BIOLOGICAL PROPERTIES OF POLYMERIC PLATINUM COMPLEXES IN AN EFFORT TO ENHANCE SOLUBILITY AND STABILITY WHILE REDUCING TOXICITY AND OBTAINING GREATER SUSTAINED ACTIVITY THAN THAT FOUND WITH ACTIVE, STRUCTURALLY RELATED, MONOMERIC COMPLEXES. THE PHASE I RESEARCH PLAN IS BASED ON THE PROMISING PRELIMINARY IN VIVO RESULTS OBTAINE ...

ARBUS, INC., WILL EXPLORE THE FEASIBILITY OF, AND SUBSEQUENTLY DEVELOP, A COMPUTERIZED PHARMACEUTICAL TRACKING SYSTEM FOR INVESTIGATIONAL DOSAGE FORMS. DURING PHASE I, ARBUS PERSONNEL WILL FULLY DEFINE WHAT PRODUCT DOCUMENTATION IS REQUIRED AND WHAT METHOD IS PREFERRED FOR THE SYSTEM USERS TO INTERACT WITH THE PROPOSED SYSTEM. KEY DEVELOPMENT DOCUMENTATION WILL BE DRAFTED CLARIFYING THE COMPUTER H ...

THE EFFORT TO DEVELOP ARTIFICIAL HEARING SYSTEMS FOR THE DEAF HAS RECENTLY BEEN FOCUSED ON TACTUAL VOCODERS, DEVICES THAT TRANSDUCE ACOUSTIC ENERGY INTO VIBRATORY OR ELECTROCUTANEOUS SIGNALS WHICH ARE THEN APPLIED TO THE SKIN. CURRENT TACTUAL VOCODERS, HOWEVER, ARE BASED LARGELY UPON UNTESTED ASSUMPTIONS ABOUT OPTIMAL FILTER CONFIGURATIONS FOR SPEECH PROCESSING. IN A STUDY WHICH CAREFULLY CONTROLS ...

THE AIM OF THE PROPOSED PROJECT IS TO INVESTIGATE THE FEASIBILITY OF DEVELOPING A MICROCOMPUTER-BASED EXPERT SYSTEM TO ASSIST SCIENTISTS IN SELECTING, PERFORMING, INTERPRETING, AND REPORTING STATISTICAL PROCEDURES. OFTEN RESEARCHERS IN THE HEALTH SCIENCES ARE HIGHLY COMPETENT IN THEIR SPECIFIC AREAS OF EXPERTISE BUT INADEQUATELY TRAINED IN CHOOSING AND INTERPRETING THE STATISTICS THAT ARE APPROPRI ...