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FEASIBILITY IS EXAMINED FOR A HAND-HELD INSTRUMENT TO MEASURE THRUST FORCE AND JOINT MOTION DURING SPINAL MANIPULATION AND REHABILITATION OF PATIENTS WITH NEUROMUSCULAR APPLICATION TO THE HEALTH FIELD: PROVIDE NONINVASIVE MONITORING AND CONTROL OF FORCES APPLIED DURING PHYSICAL REHABILITATION PROCEDURES FOR THE BACK. THIS INSTRUMENTATION IS EXPECTED TO PROMOTE PATIENT SAFETY, ESPECIALLY THOSE AT R ...

AN IBM-AT-BASED MULTIFUNCTIONAL SYSTEM-CAMREAD-IS PLANNED. CAMREAD IS AN INEXPENSIVE, REAL-TIME IMAGE-PROCESSING SYSTEM WITH THE CAPABILITY OF HIGH-SPEED CHARACTER RECOGNITION TO SOLVE THE PROBLEM OF CONVERTING PRINTED DOCUMENTS INTO MACHINE-READABLE RECORDS. DIFFERENT FROM OTHER COMMERCIALLY AVAILABLE EXPENSIVE MONOFUNCTIONAL READING MACHINES, THIS SYSTEM HAS MANY UNIQUE FEATURES. FIRST, IT IS A ...

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THE MAJOR GOALS FOR THE GRAPHICAL INTERNATIONAL FOOD RETRIEVAL AND ANALYSIS PROGRAM SYSTEM WERE TO COMPLETE THE INTERACTIVE PORTION OF THE SYSTEM AND TO ALLOW FOR THE INTEGRATION OF OTHER DATABASES. THE MICROSOFT WINDOWS SOFTWARE UNDER DOS WAS CHOSEN FOR DEVELOPMENT DUE TO ITS LARGER USER BASE. DURING PHASE I, INFORMATION MANAGEMENT SERVICES, INC., DEVELOPED THE SYSTEM INTO A FULLY INTERACTIVE, GR ...

THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID ADDUCTS CLASSIFIED AS METHYLFURYLBUTYROLACTONES, ALSO REFERRED TO AS NAFOCARE B. WORKING IN COLLABORATION WITH A SYNTHETIC ORGANIC CHEMISTRY GROUP AT WEST VIRGINIA UNIVERSITY, WE HAVE DETERMINED THAT THE PARENT COMPOUND, MFBL, HAS EXTENSIVE IMMUNE POTENTIATING ACTIVITY. OUR PROJECT WILL ANALYZE FIVE NEW DERIVATIVES OF L- ...

AND ITS POTENTIAL APPLICATION TO HUMAN HYBRIDOMA TECHNOLOGY.THIS PROJECT INVOLVES DETERMINING THE ABILITY OF A NEW CLASS OF SYNTHETIC BIOLOGICAL RESPONSE MODIFIERS (BRM) KNOWN AS METHYLFURYLBUTYROLACTONES (MFBL) TO AUGMENT THE PRODUCTION OF LYMPHOKINES (IL-2, B-CELL GROWTH FACTOR, AND IMMUNE INTERFERON) AND MONOKINES (IL-1, PROSTAGLANDINS, AND CYTOLYTIC FACTOR). OUR LABORATORY HAS DETERMINED THAT ...

ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY. DATA ACCUMULATED BY OUR LABORATORIES INDICATE THAT THE METHYLFURYLBUTYROLACTONE (MFBL) CLASS OF COMPOUNDS REPRESENTS NEW SYNTHETIC IMMUNE RESPONSE MODIFIERS CAPABLE OF ACTIVATING SEVERAL COMPONENTS OF IMMUNE RESPONSE WITH NEGLIGIBLE T ...

THE OBJECTIVE OF THIS STUDY IS TO PREPARE ANTINEOPLASTIC PLATINUM COMPLEXES WITH STABILITIES IN SOLUTION GREATER THANTHAT OF 4-CARBOXYPHTHALATO(1,2-DIAMINOCYCLOHEXANE) PLATINUM (NSC 271674;DACHPT). NSC 271674 IS A CISPLATIN ANALOG INVENTED BY THE APPLICANT AND NOW IN PHASE II CLINICAL TRIALS AT MEMORIAL SLOAN-KETTERING CANCER CENTER IN NEW YORK. IT IS ACTIVE AGAINST CISPLATIN-RESISTANT TUMORS WITH ...

THE PROVEN CLINICAL EFFECTIVENESS OF CISPLATIN AS WELL AS SEVERAL SECOND GENERATION ANALOGS HAS ESTABLISHED THE ROLE OF METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY. COMPLEXES OF METALS OTHER THAN PLATINUM HAVE BEEN OFTEN POORLY DESIGNED BECAUSE THEY WERE MODELED AFTER THE ACTIVE PLATINUM COMPLEXES WITHOUT CONSIDERING THEIR DIFFERENT THERMODYNAMIC AND KINETIC PARAMETERS. IN PARTICULAR, PALL ...