Award Data

DESCRIPTION: This project addresses the alternative communication and computer access needs of individuals who, as a result of a neuromuscular disorder, e.g. cerebral palsy, are severely speech impaired and/or lack the fine motor control necessary to use direct selection to access an Augmentative and Alternative Communication (AAC) device or computer. Currently these indi ...

DESCRIPTION: This project addresses the alternative communication and computer access needs of individuals who, as a result of a neuromuscular disorder, e.g. cerebral palsy, are severely speech impaired and/or lack the fine motor control necessary to use direct selection to access an Augmentative and Alternative Communication (AAC) device or computer. Currently these indi ...

Active Signal Technologies proposes to further develop its self applied, electrodeless home monitoring device for sleep apnea with the ultimate goal of making clinical diagnosis available to a much larger population of sleep disorder patients than currently possible. Preliminary results from Phase I have shown that much of the diagnostically rich airflow information captured in the sleep lab with ...

Active Signal Technologies proposes to further develop its self applied, electrodeless home monitoring device for sleep apnea with the ultimate goal of making clinical diagnosis available to a much larger population of sleep disorder patients than currently possible. Preliminary results from Phase I have shown that much of the diagnostically rich airflow information captured in the sleep lab with ...

DESCRIPTION: Public Data Queries, Inc., will create an interactive chartbook on Aging in America, covering the period from 1940 through the present. This chartbook will identify and describe the social, economic and demographic trends that are now changing the older population of the United States. It will be distributed in hard copy with an accompanying electronic ...

APPLICANT?S DESCRIPTION: Gene therapy will allow for the treatment of both acquired and genetic diseases at the most fundamental level by introduction of therapeutic genes. Despite advances in delivery of foreign genes, achieving high and stable levels of expression has been problematic. The use of plasmid DNA for gene therapy has many advantages, including safety, accommodation of large genes, ea ...

DESCRIPTION (provided by applicant): This proposal is directly applicable to the Protein Structure Initiative. A major bottleneck in the initiative is the capability to obtain quality diffractable protein crystals for structure elucidation. The automated DCCS system described in this proposal has been designed to minimize the effects of the protein crystal bott ...

DESCRIPTION (Verbatim from Applicant's Abstract): Our goal is to construct a prototype chamber with protocols for the manufacture of a new low-voltage electroporation (LVEP) system to transfect suspended and adherent cells under physiologic conditions. Electric field amplification results from embedding the cells into the pores of thin (13 um) insulating filters, ena ...

DESCRIPTION (Verbatim from Applicant's Abstract): Our goal is to construct a prototype chamber with protocols for the manufacture of a new low-voltage electroporation (LVEP) system to transfect suspended and adherent cells under physiologic conditions. Electric field amplification results from embedding the cells into the pores of thin (13 um) insulating filters, ena ...

DESCRIPTION (provided by applicant): Parkinson's disease (PD) affects 1 percent of the population over 60 years of age and is one of the most common motor disorders. A pathologic hallmark of PD is the deposition of intracellular protein inclusions known as Lewy bodies in the neurons of affected individuals. The protein alpha-synuclein is a primary component of Lewy b ...