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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 377: Symptom Management and Intervention Roadmaps (STaIRS)

    SBC: Carevive Systems, Inc.            Topic: NCI

    Numerous adverse symptoms are under-detected in cancer care resulting1-3 in missed opportunities for intervention; leading to poor treatment adherence, avoidable hospitalizations, and worse morbidity and survival. The IOM proposed shaking up the current symptom paradigm from reactive to proactive, personalized, technology-enabled models of symptom care as a solution to this clinical quality crisis ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Framework for High-Confidence Hardware Trojan Detection (HTD)

    SBC: The Athena Group, Inc.            Topic: SB173004

    Malicious modifications of hardware pose major concern in terms of reliable and trusted field operation of integrated circuits. To ensure security and trust of micro-chips, it is essential to develop efficient, low-cost techniques for detection of such tampering events. Conventional structural/functional testing, coverage metrics, and test generation approaches cannot be readily applied to identif ...

    SBIR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  3. A novel biomaterial based therapy utilizing auto antigen and adjuvant for the amelioration of Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Immune mediated diseases such as type diabetes T D multiple sclerosis rheumatoid arthritis and systemic lupus erythematosis are reaching epidemic proportions in the US T D affects an estimated million Americans with more than new patients diagnosed annually resulting in roughly $ B in health care costs in the US each year T D is an autoimmune disease characterized by effector ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. An interactive App to Promote Safe and Effective use of Opioids in Young Children Postoperatively

    SBC: ARCHIE MD INC.            Topic: NIDA

    In recent years increased attention to pain in children and adolescents has led to a recent fold increase in opioid prescriptions Unsurprisingly the annual rates of analgesic related adverse drug events AR ADEs have soared to include andgt hospital admissions and hundreds of accidental overdose deaths in children and adolescents and has remained a significant problem At the heart of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Developing specific rapid and cost effective immunoassays for Zika detection

    SBC: MEDIOMICS, LLC            Topic: R

    This proposal aims to develop highly specific rapid and cost effective immunoassays to detect Zika virus ZIKV infection ZIKV is a single stranded RNA virus in the Flaviviridae family that is transmitted to humans through infected mosquitos blood transfusions and sexual contact As of June around Zika Virus disease cases have been estimated in Brazil alone Recently ZIKV has be ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Biomaterial based delivery of Interleukin to Regulatory T Cells for the amelioration of Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Type Diabetes T D results from a breakdown of self tolerance that is characterized by immune cell mediated destruction of the insulin producing cells in the pancreas Ultimately glucose metabolism is interrupted resulting in the development of life threatening complications such as heart disease and renal failure T D affects an estimated million Americans with more than new patie ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting the alternative pathway to treat age related macular degeneration

    SBC: Serion, Inc            Topic: N

    Targeting the alternative pathway of complement to treat age related macular degeneration Abstract Age related macular degeneration AMD is the leading cause of vision loss in the developed world in people over and is a priority research area for the National Eye Institute It is a progressive degenerative disease that causes loss of the central vision due to destruction of the part of the re ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. The Preemie Pacer An Innovative Bottle to Promote Safe and Efficient Oral Feeding in Preterm Infants

    SBC: Preemie-Pacer, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT There are infants born preterm each year in the United States alone Preterm infants often necessitate care in the neonatal intensive care unit One of the final milestones to be achieved in order to be discharged from the neonatal intensive care unit is oral feeding Oral feeding can be a challenge for infants born preterm as they do not have the maturity that all ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Disaggregation of Toxic Protein Oligomers in Brain with Electromagnetic Treatment

    SBC: NeuroEM Therapeutics, Inc.            Topic: 104

    ABSTRACT Formation of misfolded protein oligomers in neurons is an early and causative event in a variety of neurodegenerative diseases such as Alzheimer s Disease amyloid and tau oligomers Fronto temporal lobe dementia tau oligomers and Parkinson s Disease synuclein oligomers These toxic oligomers share a common aggregation mechanism that involves formation of hydrogen bonds betwee ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Application of PPODA QT for embolization of aneurysms

    SBC: Aneuvas Technologies, Inc.            Topic: 101

    A cerebral aneurysm is an abnormal enlargement or pouch that forms from a weakened vessel segment in the brain Often going unnoticed and untreated an aneurysm can cause a sudden and catastrophic hemorrhage or stroke Approximately of patients die from an aneurysm rupture even before receiving medical attention and of patients die despite medical treatment Patients that survive typical ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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