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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. To develop a nanoSPRi sparing assay.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Proposes to develop a novelstandardized immune assay that improves monitoring of several biomarkerscytokinesassociated with immunologic pathways of AD with the constraint of having a limited amount of biological samplesThis overall goal is supported by the following program objectivesPhase IDemonstrate proof of concept of nanoSPRiSAas a sensitive and efficient technique in assessing cytokines in h ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. The objective of this contract is to develop a novel LBL RNA vaccine that can be administered to induce long-lasting protection against HIV challenge.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Extensive efforts have gone towards safe and effective vaccines for Human Immunodeficiency VirusHIVprevention and treatmentAlthough many strategies have been attempted for HIV vaccine developmentnone have been successfully establishedOne category of vaccines gaining increased popularity is RNA based vaccineswhich are vaccines containing antigens encoded by RNA and can be delivered by viral or usin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. GR-TDM: A Framework for Design Space Exploration of Hardware Trojan Detection and Mitigation Tradeoffs

    SBC: Graf Research Corporation            Topic: SB173004

    As integrated circuit dimensions shrink and U.S. fabrication facilities age, U.S. ASIC developers are increasingly turning to overseas foundries for the latest process nodes in device fabrication.This migration is especially impactful for DoD designers as critical military technology needs to be trusted and offshore fabrication has the potential to expose chips to malice during manufacture.Sensiti ...

    SBIR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  5. An Integrated Pan Genome Resistome Platform for Nosocomial Pathogen Surveillance in Hospitals

    SBC: ICBiome            Topic: NIAID

    Nosocomial hospital infections are a significant public health concern as they severely harm patients disrupt normal operations and increase hospital costs To reduce these risks and allow for preemptive responses there is a critical need for routine surveillance of nosocomial pathogens within a hospital environment patients staff ventilation equipment With the decreasing costs of sequenci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Developing specific rapid and cost effective immunoassays for Zika detection

    SBC: MEDIOMICS, LLC            Topic: R

    This proposal aims to develop highly specific rapid and cost effective immunoassays to detect Zika virus ZIKV infection ZIKV is a single stranded RNA virus in the Flaviviridae family that is transmitted to humans through infected mosquitos blood transfusions and sexual contact As of June around Zika Virus disease cases have been estimated in Brazil alone Recently ZIKV has be ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting the alternative pathway to treat age related macular degeneration

    SBC: Serion, Inc            Topic: N

    Targeting the alternative pathway of complement to treat age related macular degeneration Abstract Age related macular degeneration AMD is the leading cause of vision loss in the developed world in people over and is a priority research area for the National Eye Institute It is a progressive degenerative disease that causes loss of the central vision due to destruction of the part of the re ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. The Preemie Pacer An Innovative Bottle to Promote Safe and Efficient Oral Feeding in Preterm Infants

    SBC: Preemie-Pacer, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT There are infants born preterm each year in the United States alone Preterm infants often necessitate care in the neonatal intensive care unit One of the final milestones to be achieved in order to be discharged from the neonatal intensive care unit is oral feeding Oral feeding can be a challenge for infants born preterm as they do not have the maturity that all ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Promoting AdheRence via Objective Technology to Assess Cystic Fibrosis Treatment PROTRACT

    SBC: BARRON ASSOCIATES, INC.            Topic: NHLBI

    Significance The proposed research Promoting AdheRence via Objective Technology to Assess Cystic Fibrosis Treatment PROTRACT will develop a novel cost effective system that combines multiple sensing modalities to provide an accurate practical and affordable method for reliably assessing adherence to treatment of cystic fibrosis CF Problem to be Addressed CF is a life shortening disea ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Disaggregation of Toxic Protein Oligomers in Brain with Electromagnetic Treatment

    SBC: NeuroEM Therapeutics, Inc.            Topic: 104

    ABSTRACT Formation of misfolded protein oligomers in neurons is an early and causative event in a variety of neurodegenerative diseases such as Alzheimer s Disease amyloid and tau oligomers Fronto temporal lobe dementia tau oligomers and Parkinson s Disease synuclein oligomers These toxic oligomers share a common aggregation mechanism that involves formation of hydrogen bonds betwee ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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