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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Goldmann Contact Tonometry with Optimized Error Correction

    SBC: INTUOR TECHNOLOGIES LLC            Topic: N

    DESCRIPTION provided by applicant Intraocular pressure IOP is arguably the second most important criteria used to assess visual acuity when eye care professionals are diagnosing treating and managing patients The patented Intuor Applanation Tonometer IAT prism design is a novel and simple approach for improving the accuracy of IOP measurement in the eye The proposal describes an inexpen ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Kinome wide Cell Based Assays

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: 300

    DESCRIPTION provided by applicant The human genome encodes protein kinases that catalyze the phosphorylation of client proteins Signal transduction mediated by protein impacts virtually all aspects of cellular physiology from the coordination of the cell cycle and cll division to apoptosis Not surprisingly the deregulation of kinases is implicated in many diseases including diabetes in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Scalable amperometric microchip array for high throughput screening of small molecules peptides or genetic perturbations for modulation of quantal transmitter release

    SBC: EXOCYTRONICS, LLC            Topic: 101

    ` The goal of this project is the development of a scalable n x m electrochemical detector array platform with on chip amplifiers for massively parallel recordings of quantal transmitter release events The neurobiological process that this assay analyzes is the process of exocytosis and transmitter release Neurotransmitters and hormones are stored at high concentration in membrane bound organel ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Sustained release gel enabling one stage treatment of prosthetic joint infection

    SBC: SONORAN BIOSCIENCES, INC.            Topic: NIAMS

    Principal Investigator Overstreet Derek J Abstract Sonoran Biosciences Inc SBIR PAR Direct Phase II Prosthetic joint infections PJIs are especially costly requiring two surgeries at a cost of approximately $ per case to treat more than hip and knee replacement infections each year The near term outlook in this area is bleak with the number of infections growing ov ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Activate Silent and Cryptic Intact Fungal SM Gene Clusters through FACs for Novel Antibiotics Discovery

    SBC: Intact Genomics Inc.            Topic: NIAID

    PROJECT SUMMARY According to a CDC report antibiotic resistant infections are associated with deaths and million illnesses in the United States each year The estimated annual impact of antibiotic resistant infections on the national economy is $ billion in excess direct health care costs and in lost productivity from hospitalizations and sick days The emergence of drug resistant mic ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A Search Engine for Heterogeneous Information Needs in the Clinical Workflow

    SBC: MEDSOCKET OF MISSOURI, INC.            Topic: NLM

    DESCRIPTION provided by applicant Modern clinical practices represent a prototypical information intensive distributed and collaborative environment where physicians struggle to find the right information at the right time to make effective clinical decisions The situation is exacerbated not only by federal guidelines and policies regarding compliance to clinical quality metrics and meaningf ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Human Apyrase Therapy for Acute Ischemic Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: 105

    Principal Investigator Program Director Last First Middle Chen Ridong Abstract There remains a crucial unmet medical need in acute ischemic stroke AIS treatment Approximately of patients die within one year and are permanently disabled making AIS the fourth leading cause of death and the leading cause of adult disability in the USA with an estimated cost range of $ ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a fiber optic high dynamic range magnetic field gradiometer operable in unshielded environments

    SBC: TIPD, LLC            Topic: SB161005

    Proposed, is a low cost fiber optic high dynamic range magnetic field gradient measurement system for noninvasive, real-time monitoring of bio-magnetic activities with high spatiotemporal resolution in unshielded environment. Each gradient measurement system would consist of 1 scalar magnetometer, 1 each of horizontal and vertical gradiometers, and additional scalar magnetometers for background ma ...

    SBIR Phase I 2016 Department of DefenseDefense Advanced Research Projects Agency
  10. Scalable Collaborative Cancellation Radio

    SBC: Bedford Signals Corporation            Topic: SB151005

    DARPA is seeking to develop the system components for enabling disconnected platforms to collaboratively null interference in order to communicate from one collaboration group to another. Our focus is on achieving the best performance within the constraints of practical radio limitations, such as the maximum transmit data rate, the number of simultaneous transmissions a radio can receive, and the ...

    SBIR Phase II 2016 Department of DefenseDefense Advanced Research Projects Agency

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