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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting galectin-3 for prostate cancer therapy

    SBC: GLYCOMANTRA INC.            Topic: NCI

    DESCRIPTION provided by applicant Galectin a beta galactoside binding lectin is involved in the progression of many cancers In our recent publication in PNAS PMC we have shown that in prostate cancer galectin promotes tumor angiogenesis tumor endothelial cell adhesion and metastasis and also evades immune surveillance through killing of infiltrating T cells To block galecti ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Goldmann Contact Tonometry with Optimized Error Correction

    SBC: INTUOR TECHNOLOGIES LLC            Topic: N

    DESCRIPTION provided by applicant Intraocular pressure IOP is arguably the second most important criteria used to assess visual acuity when eye care professionals are diagnosing treating and managing patients The patented Intuor Applanation Tonometer IAT prism design is a novel and simple approach for improving the accuracy of IOP measurement in the eye The proposal describes an inexpen ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Controlled Release Polymer Structures for In Situ Chemical Oxidation of Contaminated Groundwater

    SBC: AxNano, Llc            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA estimates that one out of every four Americans lives within three miles of a hazardous waste site Over brownfield sites are awaiting remediation and sites on the National Priorities List Potential Responsible Parties or the Superfund program are tasked with remediating these sites but insufficient funding and growing number of sites hav ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Models for the Prediction of Ventilator Associated Conditions in the Hospital Setting

    SBC: Origent Data Sciences, Inc.            Topic: 600

    ABSTRACT Mechanical ventilation refers to the use of life support technology to perform the work of breathing for patients suffering from respiratory failure Patients undergoing mechanical ventilation are disproportionately older and suffer from multiple chronic conditions Approximately half of these patients are older than and half suffer from multiple chronic conditions Prolonged mechanic ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Scalable amperometric microchip array for high throughput screening of small molecules peptides or genetic perturbations for modulation of quantal transmitter release

    SBC: EXOCYTRONICS, LLC            Topic: 101

    ` The goal of this project is the development of a scalable n x m electrochemical detector array platform with on chip amplifiers for massively parallel recordings of quantal transmitter release events The neurobiological process that this assay analyzes is the process of exocytosis and transmitter release Neurotransmitters and hormones are stored at high concentration in membrane bound organel ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Human Apyrase Therapy for Acute Ischemic Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: 105

    Principal Investigator Program Director Last First Middle Chen Ridong Abstract There remains a crucial unmet medical need in acute ischemic stroke AIS treatment Approximately of patients die within one year and are permanently disabled making AIS the fourth leading cause of death and the leading cause of adult disability in the USA with an estimated cost range of $ ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a fiber optic high dynamic range magnetic field gradiometer operable in unshielded environments

    SBC: TIPD, LLC            Topic: SB161005

    Proposed, is a low cost fiber optic high dynamic range magnetic field gradient measurement system for noninvasive, real-time monitoring of bio-magnetic activities with high spatiotemporal resolution in unshielded environment. Each gradient measurement system would consist of 1 scalar magnetometer, 1 each of horizontal and vertical gradiometers, and additional scalar magnetometers for background ma ...

    SBIR Phase I 2016 Department of DefenseDefense Advanced Research Projects Agency
  9. ANOMALOUS PROPAGATION COMMUNICATIONS SYSTEM (APCS)

    SBC: SHARED SPECTRUM COMPANY            Topic: SB161006

    Shared Spectrum Company and HS Owen LLC propose a program to develop and demonstrate innovative methods to increase the predictability and realization of long link distance maritime communications to support mission planning and enable new mission capabilities. Anomalous propagation (i.e., ducting) leads to significantly increased link ranges. The project purpose is to develop the Anomalous Propag ...

    SBIR Phase I 2016 Department of DefenseDefense Advanced Research Projects Agency
  10. Flexible Low-Modulus Nanofiber-Based TIME Nerve Interfaces

    SBC: Luna Innovations Incorporated            Topic: SB153001

    Breakthroughs in the development of neural interface technologies have been prevelent over the last decade, in large part due to the success of DARPA-funded technologies under the Reliable-Neural Interface Technology (RE-NET) program. These advancements have included state-of-the-art prosthetics controlled by neural interfaces as well as implementation of sensitization using interfaced prosthetics ...

    SBIR Phase I 2016 Department of DefenseDefense Advanced Research Projects Agency

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