Award Data

Energy-Efficient Extreme Winter Solar Greenhouse for Urban Farms in Rapid City SDProject SummaryThis collaborative proposal from Shende LLC in partnership with the researchers from theSouth Dakota School of Mines and Technology (SDSMT) Rapid City SD seeks to develop anEnergy Efficient Extreme Winter Solar Greenhouse product.Rapid City (RC) was declared as one of the cities with the most unpredicta ...

NanoSonic is a small advanced materials company with expertise in development of blast resistantmaterials coatings to make homes fire-resistant and 3D printing that can be scaled to printinghouses. To allow rapid manufacturing of homes and agricultural infrastucture in rural communitiesfollowing a disaster NanoSonic shall develop new concrete formulations for direct integration byAlquist 3D into g ...

The U.S. sugar beet industry contributes to 55-60% of the national sugar production and creates140000 jobs in over 20 states with ~$20B annual positive input to the economy. However with theongoing climate changes the industry is facing an increasing threat from a root rot disease knownas Rhizoctonia Crown and Root Rot (RCRR) caused by a fungal pathogen Rhizoctonia solanitogether with a bacterial ...

Kultevat Inc. aims to produce natural rubber from Taraxacum kok-saghyz (TKS) at scale toachieve high quality product at a price point that is attractive to customers in particular to US basedcompanies. To date the economics of growing TKS and extracting rubber from its roots at a pricepoint that is competitive with Hevea rubber has not been demonstrated. During Phase I research anRNAi gene silenci ...

Project Summary / Abstract Chemotherapy induced peripheral neuropathy (CIPN) is a major side effect of oxaliplatin, a key drug in 1st line regimens for treating colorectal cancer. Dose-limiting CIPN prevents rt25% of patients from receiving full, maximally effective dose of oxaliplatin. In addition, 10-40% of patients receiving oxaliplatin-based therapy for colorectal cancer with develop chronic C ...

ABSTRACT Long-term survival rates for children diagnosed with acute lymphoblastic leukemia (ALL) currently exceed 90%. However, prolonged ALL chemotherapy, which lasts two to three years on average, is associated with significant fatigue and sleep disturbances in both children and their caregivers. In fact, patients and caregivers often identify excess fatigue and sleep disturbances as the most di ...

ABSTRACT Developing drugs that target the central nervous system (CNS) is hampered by an inability to perform direct in vivo preclinical measurements. Here, we propose to identify an optimal smoking cessation drug candidate by monitoring how our newly synthesized prodrugs alter real-time brain dopamine responses to nicotine. Varenicline (CHANTIX®) is the leading FDA-approved oral medication for s ...

PROJECT SUMMARYLoss of functional mobility associated with aging is the leading cause of dangerous falls and loss of living independence. Approximately 60% of community-residing individuals rt80 years-old have a gait disorder, and abnormal gait patterns are associated with a greater than two-fold increased risk of institutionalization and death in comparison to age-related adults without gait impa ...

Project Summary/Abstract The Tiny Cargo Company offers a unique, orally administered medical countermeasure for treatment and prevention of the gastrointestinal (GI) side effects of cancer radiation therapy (RT). Our therapeutic is comprised of milk-derived extracellular vesicles (mEVs) loaded with a safe and highly effective radioprotective drug – a formulation that we call Milactatm. RT compli ...

PROJECT SUMMARY Total joint arthroplasty (TJA) procedures are estimated to rise by over 300% by the year 2030. Periprosthetic joint infection (PJI) is the most significant complication following TJA with healthcare costs exceeding $1.6 billion annually. Treatment of PJI generally requires surgical intervention combined with a prolonged course of antibiotics costing $50,000 per patient. Despite thi ...