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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Developing specific rapid and cost effective immunoassays for Zika detection

    SBC: MEDIOMICS, LLC            Topic: R

    This proposal aims to develop highly specific rapid and cost effective immunoassays to detect Zika virus ZIKV infection ZIKV is a single stranded RNA virus in the Flaviviridae family that is transmitted to humans through infected mosquitos blood transfusions and sexual contact As of June around Zika Virus disease cases have been estimated in Brazil alone Recently ZIKV has be ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting the alternative pathway to treat age related macular degeneration

    SBC: Serion, Inc            Topic: N

    Targeting the alternative pathway of complement to treat age related macular degeneration Abstract Age related macular degeneration AMD is the leading cause of vision loss in the developed world in people over and is a priority research area for the National Eye Institute It is a progressive degenerative disease that causes loss of the central vision due to destruction of the part of the re ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. The Preemie Pacer An Innovative Bottle to Promote Safe and Efficient Oral Feeding in Preterm Infants

    SBC: Preemie-Pacer, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT There are infants born preterm each year in the United States alone Preterm infants often necessitate care in the neonatal intensive care unit One of the final milestones to be achieved in order to be discharged from the neonatal intensive care unit is oral feeding Oral feeding can be a challenge for infants born preterm as they do not have the maturity that all ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. ITK TXK Inhibitors as Oral Immunotherapeutic Drugs for Psoriasis

    SBC: CONFLUENCE LIFE SCIENCES, INC.            Topic: NIAMS

    Psoriasis is a devastating autoimmune disease that manifests itself in the form of patchy inflammatory skin lesions that can appear anywhere throughout the body resulting in tremendous physical pain and discomfort This chronic disease can also cause arthritic joints and have a profound impact on a patient s psychological well being In psoriatic lesions the detection of increased numbers of T c ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Theranostics of Reduction of Cardiotoxicity Using Targeted Apoptosis Activation Technology

    SBC: Sci-Engi-Medco Solutions, Inc            Topic: 102

    Project Summary Abstract Chronic cardiotoxicity is a clinically unresolved issue for cancer patients who are treated particularly with anthracycline based drugs Currently triple negative breast cancer TNBC patients have no option but to rely on these nonspecific chemotherapeutics New technologies are needed to reduce the off target toxicity including anthracycline related cardiotoxicity A ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Immunomodulatory Therapy for Diabetic Nephropathy

    SBC: APT THERAPEUTICS, INC.            Topic: 400

    Diabetic nephropathy DN is one of the most common microvascular complications of diabetes and the leading cause of end stage renal disease in Western and Asian countries The current medical management of diabetes to prevent its complications include tight glycemic control and strict management of blood pressure these established treatments delay the onset and the progression of DN however th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Developing novel immunoassays specific for thyroid stimulating and TSH blocking autoantibodies

    SBC: MEDIOMICS, LLC            Topic: 200

    Graves disease GD is the most common cause of hyperthyroidism accounting for to percent of more than million cases of hyperthyroidism globally It is an autoimmune disorder caused by thyroid stimulating antibodies TSAbs which bind to the thyrotropin or thyroid stimulating hormone TSH receptor on the surface of a thyroid cell This leads to stimulation of the thyroid gland and ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. DEVELOPING NOVEL TOOLS FOR SITE SPECIFIC QUANTITATIVE ANALYSIS OF RNA MODIFICATIONS

    SBC: MEDIOMICS, LLC            Topic: NCI

    Although recent developments in highly sensitive technologies have revolutionized research on RNA modifications the available quantitative methods can be further improved Current methods include liquid chromatography tandem mass spectroscopy LC MS MS and next generation sequencing coupled with modification specific antibodies The LC MS MS method is not accessible to many researcher scientists ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. FDA COMPLIANT IMAGING INFORMATICS FOR CANCER RESEARCH

    SBC: Radiologics, Inc.            Topic: NCI

    Quantitative imaging has the potential to transform cancer research and diagnostics The National Cancer Instituterecently funded the Integrative Imaging Informatics for Cancer Research I CR a year grant at Washington UniversitySchool of Medicine to develop advanced imaging informatics technology to enable this transformation I CR provides arange of imaging informatics capabilities to enable ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. GeoMetrix: Rapid, Reliable, and Global Analytics using Commercial Satellite Imagery

    SBC: Vision Systems, Inc.            Topic: SB162009

    The pace of warfare is increasing rapidly with the emergence of numerous asymmetrical threats exhibiting complex interdependencies and shifting alliances. Never has it been more essential to acquire detailed tactical intelligence in time scales in hours ...

    SBIR Phase II 2017 Department of DefenseDefense Advanced Research Projects Agency

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