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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Open System Manufacturing of Large Sensing/Weapons Platforms

    SBC: Applied Radar, Inc.            Topic: SB102005

    In order to maintain our nation’s technological superiority on air, sea and land, we must respond quicker to emerging threats and reduce the cost of major sensing platforms. Every DoD platform developed nowadays contains at least one sensor, whether it be RF, EO/IR, or acoustic. In fact, in a lot of recent developments, the platform is built around the sensor and exists only to support the senso ...

    SBIR Phase I 2010 Department of DefenseDefense Advanced Research Projects Agency
  2. Combination Treatment of tPA and Apyrase for Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. Using a protein informatics approach, we have successfully engineered a human apyrase which exhibits significantly higher enzymatic activity and platelet inhibition than the wild-type ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Combination Therapy of Aspirin and Apyrase for Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. We will validate hypothesis that in thromboembolic model of stroke in rats, combination tre ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  4. TGF-beta Antagonists for Accelerating Wound Healing

    SBC: AUXAGEN, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Every year in the United States, gt1.25 million people suffer from burns, 6.5 million have chronic skin ulcers caused by pressure, venous stasis or diabetes mellitus and 0.25 million have keloids sufficiently severe to require surgery. Burn treatment costs 1.8 billion per year in the US. The treatment of persons with chronic skin ulcers costs 13 billion per y ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Facile Detection of Soil-Transmitted Helminth Infections

    SBC: Divergence, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): The goal of this project is to develop a rapid and accurate immunodiagnostic test for detection of soil- transmitted helminths (STHs) that can be used without laboratory infrastructure. Human STH infections from whipworm (Trichuris), roundworm (Ascaris), and hookworms (Necator and Ancylostoma) create a substantial burden to worldwide public h ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Direct RT-PCR detection of RNA pathogens and mRNA expression in crude samples

    SBC: DNA POLYMERASE TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to develop a highly simplified and improved method of detecting RNA for use in clinical tests and for scientific research by enabling the RT-PCR amplification of nucleic acids directly in whole blood, serum, plasma, and cell lysates. We propose a dual approach. We will work with two of our blood inhibition Taq mutants combined with a viral reverse tr ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. Nuclease Probe Mediated Sequencing

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): Sequencing is very powerful for identifying differences in genomic DNA that may regulate cell function and diseases, pre-dispose persons to certain diseases, or warn of adverse drug metabolism. It provides a basis for identifying differences in gene expression, though such applications have been limited and are problematic because each expressed gene can vary f ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. Not Available

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NIEHS

    This Phase I proposal will develop and validate assays to measure the metabolism of compounds and their affect on liver cells using a multiplexed gene expression assay platform, the quantitative Nuclease Protection Assay (qNAP¿) that can measure the expression of up to 100 mRNA and miRNA and is a simple, robust and highly precise assay that provides high sample throughput. Two cell systems wil ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  10. Not Available

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NCI

    A molecular test using FFPE tissue from patients to distinguish basal-like breast cancer from other subtypes will be developed and confirmed. The test will be based on a commercial platform, the lysis-on ly quantitative Nuclease Protection Assay (qNPA 1M). Current gene expression signatures described for breast cancer, in particular those for distinguishing basal-like breast cancer from other subt ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
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