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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Analyzing Human Dimensions of Software Engineering Processes

    SBC: APPLIED VISIONS, INC.            Topic: SB172007

    The Secure Decisions team will conduct research to: 1) determine how human dimensions of software engineering (SE) processes influence software security and quality; and 2) develop mechanisms for measuring these relationships in both open source and closed (private) development environments. The human dimensions of interest are: characteristics and behaviors of developers and development teams; en ...

    SBIR Phase II 2019 Department of DefenseDefense Advanced Research Projects Agency
  2. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Data Sandboxing for Software Binaries

    SBC: Grammatech, Inc.            Topic: SB173003

    Data-rich applications, such as web servers, web browsers, and document editors, are inherently vulnerable to non-control data attacks, i.e., attacks that exploit memory corruption vulnerabilities to leak or corrupt sensitive data. We propose Dobby, a tool that statically transforms software binaries to integrate run-time checks ensuring illicit data flows caused by memory corruption errors in the ...

    SBIR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  6. New Platform Technologies for Viral and Therapeutic Evolution Assays

    SBC: Autonomous Therapeutics, Inc.            Topic: SB171003

    From HIV to metastatic cancer, state-of-the-art therapeutics are static biological or pharmaceutical compoundswhose efficacy is inevitably lost once their evolving disease targets sufficiently mutate.We engineered the first adaptive therapeutics designed to co-adapt with adapting disease agentsto provide resistance-proof disease control. Known as Therapeutic Interfering Particles (TIPs), these the ...

    SBIR Phase II 2018 Department of DefenseDefense Advanced Research Projects Agency
  7. Identification and Modification of Features in Embedded Devices

    SBC: Red Balloon Security, Inc.            Topic: SB0142002

    Unlike conventional computers, the embedded computers found in vehicles, routers and other Internet of Things devices lack the capability to have their software remotely updated. Vulnerabilities discovered in such devices remain unpatched, creating a large and growing attack surface. We propose to address this limitation in our Identification and Modification of Features in Embedded Devices (IMFED ...

    SBIR Phase II 2018 Department of DefenseDefense Advanced Research Projects Agency
  8. Adaptive Control and Advanced Sensing for Turbine Based Combined Cycle Vehicles

    SBC: Innoveering, LLC            Topic: SB171014

    Development of air vehicles capable of routine operation and able to achieve hypersonic speeds is paced by the availability of a propulsion system.The vision is to combine improved off-the-shelf turbines for low-speed operation (M=0 to 2+) and dual-mode ramjet (DMSJ) engine technologies for high-speed operation (M=2+ to 5+), with both engines sharing a common air inlet and a common thrust producin ...

    SBIR Phase II 2018 Department of DefenseDefense Advanced Research Projects Agency
  9. Enhancing cytarabine efficacy in leukemia through CDK inhibition

    SBC: SENEX BIOTECHNOLOGY, INC.            Topic: 102

    Acute myeloid leukemia AML is the most common acute leukemia in adults with new cases annually in the US A deoxycytidine nucleoside analog Cytarabine AraC is the principal chemotherapeutic agent used in AML AraC containing chemotherapeutic regimens induce complete remission in of newly diagnosed AML patients but a substantial minority of leukemias is intrinsically resistant t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Novel injectable resiquimod formulation for treatment of metastatic cancers

    SBC: Curebiotech, Inc.            Topic: NCI

    PROJECT SUMMARY Malignant melanoma is one of the most aggressive types of skin cancer causing a large majority of skin cancer related deaths worldwide Recently there have been staggering breakthroughs with the advent of drugs that act on checkpoint inhibitors These are paradigm shifting immunotherapeutic agents not only for melanoma but for cancers in general because they harness the bodyan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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