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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. AAAPT Technology for Improving Chemotherapy

    SBC: SCI-ENGI-MEDCO SOLUTIONS, INC            Topic: NCI

    DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A BioPhysical Approach to Resuscitation Fluids

    SBC: BIOPHYZICA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Circulatory, hypoxemic or traumatic arrest claims an estimated 350,000 lives per year in the United States accounting for almost 15% of all deaths. Circulatory, hypoxemic, or traumatic arrests result in whole-body ischemia, most significantly global cerebral ischemia. Brain cells die when they no longer receive oxygen and nutrients from the blood. Because cereb ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  3. A BioPhysical Approach to Resuscitation Fluids

    SBC: BIOPHYZICA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Circulatory, hypoxemic or traumatic arrest claims an estimated 350,000 lives per year in the United States accounting for almost 15% of all deaths. Circulatory, hypoxemic, or traumatic arrests result in whole-body ischemia, most significantly global cerebral ischemia. Brain cells die when they no longer receive oxygen and nutrients from the blood. Because cereb ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. A Biophysical Therapeutic for Traumatic Brain Injury and other Battlefield Injuries

    SBC: BIOPHYZICA, INC.            Topic: SB072006

    Battlefield injuries are unique in terms of severity, types, and combinations. The ability to develop therapeutics designed to treat a broad spectrum of battle injuries is a unique opportunity with significant positive benefits. In particular, increased capillary permeability/leak and ischemia-reperfusion injuries play a significant role in military injuries such as battlefield trauma, hemorrhagi ...

    SBIR Phase I 2008 Department of DefenseDefense Advanced Research Projects Agency
  5. ACADIANA (Annotating Code for Assured Data Intent to Avoid Novel Attacks)

    SBC: ASSURED INFORMATION SECURITY, INC.            Topic: HR001120S0019001

    In the ACADIANA effort we will address the inability of modern programming language, operating system, and architectural abstractions to provide a baseline level of adequate confidentiality protections.  Until now, developers and users of software have largely relied on their programming language and operating system to ensure that confidential data isn’t leaked out of a process’ memory space ...

    STTR Phase I 2020 Department of DefenseDefense Advanced Research Projects Agency
  6. ACADIANA PHASE 2

    SBC: ASSURED INFORMATION SECURITY, INC.            Topic: HR001120S0019001

    In the ACADIANA effort, we will address the inability of modern programming language, operating system, and architectural abstractions to provide a baseline level of adequate confidentiality protections. Until now, developers and users of software have largely relied on their programming language and operating system to ensure that confidential data isn’t leaked out of a process’ memory space ...

    STTR Phase II 2021 Department of DefenseDefense Advanced Research Projects Agency
  7. A capsule-based bioconjugate vaccine to prevent Klebsiella pneumoniae infections

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Klebsiella pneumoniae is an encapsulated human pathogen capable of causing a myriad of human infections. Recently, K. pneumoniae has also emerged as one the most common causes of secondary bacterial pneumonia in COVID-19 patients. Over the last 40 years, K. pneumoniae has evolved into two distinct pathotypes, known as classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (h ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Accelerated Monte Carlo Methods for Rarefied Gas Dynamics

    SBC: CFD RESEARCH CORPORATION            Topic: N/A

    Monte Carlo simulations of rarefied gas dynamics are important for many applications. This project aims to substantially accelerate Monte Carlo (MC) algorithms and develop a rigorous and efficient computer code applicable for a wide range of Knudsen numberfrom rarefied to continuum flow regimes. This will be achieved by using implicit treatment of the collision processes, majorant frequency scheme ...

    SBIR Phase I 2003 Department of DefenseDefense Advanced Research Projects Agency
  9. ACCELERATOR CONCEPT

    SBC: InterScience, Inc.            Topic: N/A

    THE DEVELOPMENT OF AN ELECTROMAGNETIC COMPRESSION PROJECTILE ACCELERATOR THAT CAN MEET THE REQUIREMENTS FOR APPLICATION AS KINETIC ENERGY WEAPON IS PROPOSED. THE PRINCIPAL VIRTUE OF THE PROPOSED CONCEPT, IN ADDITION TO SIMPLICITY AND HIGH EFFICIENCY TYPICAL OF ELECTROMAGNETIC LAUNCHER CONCEPTS PRESENTLY UNDER DEVELOPMENT IS ITS EXPECTED RELIABILITY DUE TO THE FACT THAT, IN CONTRAST TO RAIL GUNS, C ...

    SBIR Phase I 1986 Department of DefenseDefense Advanced Research Projects Agency
  10. Accessible Analysis of Major Drug Surveys

    SBC: SOCIAL SCIENCES INNOVATIONS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): There is a growing trend to make public-use data of all kinds directly available to consumers of those data without the need for skilled, technologically-proficient programmers to deliver reports. This project will pro

    SBIR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
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