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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Analyzing Human Dimensions of Software Engineering Processes

    SBC: APPLIED VISIONS, INC.            Topic: SB172007

    The Secure Decisions team will conduct research to: 1) determine how human dimensions of software engineering (SE) processes influence software security and quality; and 2) develop mechanisms for measuring these relationships in both open source and closed (private) development environments. The human dimensions of interest are: characteristics and behaviors of developers and development teams; en ...

    SBIR Phase II 2019 Department of DefenseDefense Advanced Research Projects Agency
  2. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Optimized Dry Powder Formulation and Delivery for Inhaled Clofazimine

    SBC: CREARE LLC            Topic: NIAID

    Treatment regimens for multi drug resistant tuberculosisMDR TBinvolve a spectrum of second tier drugs delivered over a long periodoften over a yearA drug that has shown promise in short regimenssuch as the Bangladesh regimenis oral ClofazimineCFZbut tolerance to oral CFZ is limitedInhaled delivery could potentially limit adverse effects and maximize delivery to the infected pulmonary tissueFormula ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Discovery of novel helminth immunomodulatory proteins for autoimmune diseases

    SBC: CELDARA MEDICAL, LLC            Topic: NIAID

    This contract aims to identify novel parasite derived protein candidates as biologics to treat Crohn s and other diseases with high healthcare costs and no truly long term effective treatment optionsWe will screen stage specific proteins from Onchocerca volvulus that conceivably enable this parasitic helminth to chronically infect the human host by continuously modulating the innate and adaptive i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Data Sandboxing for Software Binaries

    SBC: Grammatech, Inc.            Topic: SB173003

    Data-rich applications, such as web servers, web browsers, and document editors, are inherently vulnerable to non-control data attacks, i.e., attacks that exploit memory corruption vulnerabilities to leak or corrupt sensitive data. We propose Dobby, a tool that statically transforms software binaries to integrate run-time checks ensuring illicit data flows caused by memory corruption errors in the ...

    SBIR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  8. Advanced Technologies for Reducing Decompression Obligation and Risk

    SBC: CREARE LLC            Topic: SB131004

    Despite over 100 years of research, decompression sickness (DCS) remains the mission-limiting factor in the design and execution of combat diving operations.Divers may spend over an hour decompressing after spending as little as ten minutes at the target depth.While decompressing, divers are limited in vertical mobility, making then susceptible to detection and threatening their survivability.This ...

    STTR Phase II 2018 Department of DefenseDefense Advanced Research Projects Agency
  9. Processes for Fabrication of Atomically Precise Strongly Correlated Materials

    SBC: Xallent LLC            Topic: ST17C002

    Developing knowledge-driven nanoelectronics for military applications requires understanding the fundamental physics that governs the behavior of the underlying materials. Strongly correlated materials have very desirable properties such as interfacial superconductivity, ferroelectricity, ferromagnetism, and huge magnetoresistance, which make them an ideal set of candidates to integrate with semic ...

    STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
  10. New Platform Technologies for Viral and Therapeutic Evolution Assays

    SBC: Autonomous Therapeutics, Inc.            Topic: SB171003

    From HIV to metastatic cancer, state-of-the-art therapeutics are static biological or pharmaceutical compoundswhose efficacy is inevitably lost once their evolving disease targets sufficiently mutate.We engineered the first adaptive therapeutics designed to co-adapt with adapting disease agentsto provide resistance-proof disease control. Known as Therapeutic Interfering Particles (TIPs), these the ...

    SBIR Phase II 2018 Department of DefenseDefense Advanced Research Projects Agency

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