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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Nanoliter Lab-on-a-Chip for Rapid Parallel Immunoassays

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): The great need for more efficient and effective oncologic drug development has driven the discovery and integration of biomarkers into all phases of clinical research. Further still, biomarkers are entering the clinical arena as early means of determining which patients are likely benefiting from a particular drug. One field of targeted therapy that has relied ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  2. Multiplexing Cancer Sample Preparation: Indirect Immunomagnetic Enrichment

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Biomarkers of clinical activity are critical for targeted anti-cancer therapy development and are becoming important for the care of individual patients. In a prototypical tyrosine kinase pathway, governed by the epider mal growth factor receptor (EGFR), functional activity of the pathway is assessed by the phosphorylation status of EGFR and downstream signalin ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  3. Localized Growth Factor Therapy for Surgical Hernia Repair

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Over 700,000 surgical hernia repairs are performed each year in the United States and despite recent advances, a significant rate of recurrence persists. The incorporation of biocompatable mesh to strengthen the abdomi nal fascia has largely replaced high-tension suturing techniques in hernia repair. Currently, the preferred biomaterials include durable synthe ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  4. Antibiotic-binding Peptides for Biofilm Prevention on Ventriculoperitoneal Shunts

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Ventriculoperitoneal (VP) shunts are used to treat pediatric and neonatal hydrocephalus in severe cases, representing approximately 1/3rd of affected infants. Due to the high susceptibility for infection and mechanica l breakdown, the failure rate of VP shunts is around 30-40%. A need therefore exists to improve infection prevention for this procedure, likely ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Tissue-targeted Antibiotics for the Prevention of Surgical Site Infection

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The Centers for Disease Control estimates that as many as 2 million people contract infections in hospitals each year, with as many as 100,000 deaths. Approximately 1/4 of hospital related infections (~500,000) are surg ical site infections. For each single patient, surgical site infections have been reported to require a median 6.5 additional days of hospital ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. Self Assembling High Affinity Peptides for Point of Care Drug-Device Combinations

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Infection surrounding metal implants is a common and sometimes devastating cause of implant failure in a number of fields including oral, craniomaxillofacial (CMF), orthopedic, and cardiovascular surgery. These infectio ns, which arise from the establishment of biofilms on device surfaces, not only necessitate new surgeries but in themselves present a significa ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Prohealing Coatings for Cardiovascular Implants

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Summary Improving cardiovascular implants to reduce thrombosis and other confounds has been a long-term goal of medical science. Grafts and endovascular stents have been recently modified to include new materials, atta ched cells or drug-eluting polymers to make them more biocompatible. While these efforts represent substantial progress, the progression from i ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  8. Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental Applications

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): According to the National Institute of Dental and Craniofacial Research, 86% of adults over 70 years of age have at least moderate periodontitis with over a quarter having lost their teeth, resulting in serious health a nd quality of life repercussions. Bone grafting is routinely necessary prior to the placement of Dental implants due to bone loss caused by per ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  9. Point of Care Attachment of Antibiotics onto Metal Implants

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Infection surrounding metal implants is a common and sometimes devastating cause of implant failure in a number of fields including oral, craniomaxillofacial (CMF), orthopedic, and cardiovascular surgery. These infectio ns, which arise from the establishment of biofilms on device surfaces, not only necessitate new surgeries but in themselves present a significa ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  10. Click Chemistry for Immobilized Bone Morphogenetic Protein

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Growth factors are potent signaling molecules, initiating essential cellular programs for differentiation, proliferation and survival. Only recently have large molecules like growth factors, been employed to enhance the efficacy and specificity of medical implant therapies. In particular, procedures that require native tissues to interact with an implanted mat ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
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