Award Data

We propose a combined modeling and experimental program to analyze and optimize a turbine behind a pulse detonation combustor/engine (PDC/PDE). In Phase I, a discontinuous-Galerkin, harmonic balance code from the University of Cincinnati (UC) will be impl

Recent studies have shown that embedded systems are extremely vulnerable to security attacks. Some published exploits include remote hijacking of the electronic systems in a modern car and using IP phones and smart televisions to perform covert surveillance of their owners. In this project, we propose a protection system that automatically detects and removes vulnerabilities from embedded software ...

The ability to readily and rapidly detect the concentration of the 9- and 12-amino acid oxytocin analogs will significantly enhance the efficacy of understanding the conditions under which oxytocin is employed by the body. Ionica Sciences will take advantage of recent miniaturization of highly sensitive instrumentation that allows field application of surface enhanced Raman scattering (SERS), a sp ...

Addressing PTSD and related stress reactions by Service Members and Veterans is one of our country's most important public health challenges. Art therapy has been recognized as a powerful tool enabling"trauma survivors to symbolically express, process and contain feelings they find difficult or impossible to put in to words"(Buk, 2009). Enabling Service Members and Veterans to tell their st ...

AuraSense Therapeutics is developing oligonucleotide-modified gold nanoparticles called Spherical Nucleic Acid (SNA) constructs, which are a powerful new way of regulating cellular gene expression. AuraSense Therapeutics will use SNAs as genetically programmable antimicrobial agents in a manner to provide a rapid and effective way to develop next-generation antibacterial agents. The outcome of thi ...

Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established in Phase I of this work. The proposed breadboard system will use genomic sequencing data generated ...

DESCRIPTION (provided by applicant): CD47 has emerged as a novel therapeutic target in hematologic cancers. Leukemias expressing the highest levels of CD47 have the worst prognosis. Increased CD47 expression is thought to protect cancer cells from phagocytic clearance by sending a don't eat me signal to macrophages via SIRPa, an inhibitory receptor that prevents phagocytosis of CD47-bearing ...

DESCRIPTION (provided by applicant): This proposal aims to develop a novel, highly-specific targeted therapy for treatment of breast cancer. The long-term objective is to convert the proprietary intellectual property, the mouse monoclonal antibody (McAb)JAA-F11, which targets the pancarcinoma Thomsen-Friedenreich antigen (TF-Ag) to a humanized form for use as an adjunct with conventional therapy ...

DESCRIPTION (provided by applicant): Agave BioSystems and Professor Makoto Kuro-o at the University of Texas Southwestern Medical Center are proposing a collaborative effort to screen for novel small molecules acting as agonists or antagonists of the Klotho and Klotho- dependent endocrine Fibroblast Growth Factors. The expected outcome of this Phase I effort will be the validation of a high-throug ...

DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) involve chronic inflammation of all or part of the digestive tract. Symptoms may include abdominal pain, severe diarrhea and malnutrition. IBD primarily includes ulcerative colitis (UC)and Crohn's disease (CD). In the West, the prevalence has increased in the past 50 years to 120-200/100,000 persons for UC and 50-200/100,0 ...