Award Data

DESCRIPTION (provided by applicant): Liver fibrosis is a form of scar formation that is found in almost all patients with chronic injury to the liver. Over time it frequently progresses to cirrhosis, an end-stage lethal disease which is the seventh leadingcause of death in the United States and afflicts hundreds of millions of people worldwide. Alcohol intake remains the most important cause of li ...

N/A

N/A

IN A WIDE VARIETY OF MILITARY MISSIONS, THE DETECTION AND IMAGING OF EXTREMELY LOW LEVELS OF LIGHT IS NECESSARY. PRESENT DAY SYSTEMS INCORPORATE HIGH DENSITY CHARGE COUPLED DEVICES (CCD) WITH PIXEL SIZES AS SMALL AS 9 X 9 MICRONS. FOR EXAMPLE, THESE DETECTORS FORM THE HEART OF SOME LASER RANGING/TRACKING SYSTEMS AND ARE INVALUABLE BECAUSE OF THEIR SHORT RISE TIMES AND HIGH SENSITIVITY. HOWEVER, TH ...

DESCRIPTION (provided by applicant): The renin-angiotensin-aldosterone system (RAAS) plays a critical role in renal physiology. Inhibitors of angiotensin-converting enzyme (ACE) or angiotensin receptor blockers (ARB) are the mainstay in the clinical management of renal disorders such as chronic kidney disease (CKD). These treatments are thought to work in large part by reducing serum and renal ald ...

DESCRIPTION provided by applicant Significant obstacles exist in care delivery that prevents meaningful utilization of mental health services by consumers who experience health disparities Specifically individuals facing isolation due to linguistic literacy or cultural bariers often face challenges in procuring mental health care These challenges are in part due to the medical and mental systemsan ...

DESCRIPTION (provided by applicant): There is increasing interest in the exposure science field in top-down approaches to studying human environmental exposures (the exposome), where toxicants of interest are profiled within the body through blood and/or other biological samples. Such studies would complement more traditional bottom-up approaches where the environment in which an individual lives ...

DESCRIPTION (provided by applicant): Calista Therapeutics has discovered a first-in-class, proprietary PDZ1-2 lead drug, AT010, that is being optimized and developed as an inhaled daily therapy for cystic fibrosis (CF). CF is a deadly inherited genetic disorder that disrupts chloride channel function, resulting in the buildup of sticky mucus in patient's lungs and other organs.CF patients hav ...

DESCRIPTION (provided by applicant): Bullying, in its most familiar form, is a serious public health concern. This is especially true among middle-school age children. However, the recent increase in social networking websites coupled with the increased availability of more advanced personal devices with a broader range of social applications has dramatically increased the possible types of bullyi ...

DESCRIPTION (provided by applicant): This Lab to Marketplace SBIR Phase I Phase II Fast Track Application has as its long- term objective to establish ultrasound as a safe, effective, and non-invasive method for assessing fracture risk, an important component in clinical management of osteoporosis. Osteoporosis afflicts over 20 million people in the U.S., and is responsible for more than 275,000 ...