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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 105

    DESCRIPTION provided by applicant Sanfilippo syndrome mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is presently no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which pla ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Image guided Planning System for Skull Correction in Children with Craniosynostosis Phase II

    SBC: Kitware, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Craniosynostosis is the premature fusion of cranial sutures and occurs in approximately one in live births It results in cranial malformation that can lead to elevated intra cranial pressure brain growth impairment and developmental deficiency The most common treatment option for craniosynostosis is surgery Currently surgical treatment planning of c ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Sylvatica I Corps Commercialization Jan High Subzero Equilibrium VCA Cryopreservation

    SBC: Sylvatica Biotech, Inc.            Topic: R

    DESCRIPTION provided by applicant This program targets the long term preservation of vascularized composite tissues for both autologous and allotransplantation VCA such as of e g muscle flaps digits faces and whole limbs to radically improve restorative and reconstructive medicine We have conceived an integrated two pronged approach in which we will develop new nature inspired and furt ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel TLR Agonist Based Adjuvant for Poliovirus Vaccine

    SBC: BUFFALO BIOLABS, LLC            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Antiviral vaccines remain the largest segment of the rapidly growing global vaccine market Despite near complete eradication of poliovirus through vaccination efforts continued need for inactivated polio vaccine IPV is projected to reach million doses per year worldwide Among major obstacles to widespread use of the current IPV formulation are its high cost and in ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. rhMFG E as an Effective Adjuvant Therapy for Hemorrhagic Shock

    SBC: THERASOURCE, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant The primary objective of this project is to further demonstrate the feasibility of developing recombinant human milk fat globule epidermal growth factor factor rhMFG E as a novel and effective adjuvant therapy for the resuscitation of patients with hemorrhagic shock Hemorrhagic shock is a major cause of mortality worldwide In the United States traumatic ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Tau Oligomer Platform Validation Using Lead Series Candidate in htau Mice

    SBC: Oligomerix, Inc.            Topic: NIA

    DESCRIPTION provided by applicant The prevalence of Alzheimerandapos s disease AD is increasing worldwide due to demographic shifts resulting from an aging population It is the most costly disease in the US with a financial burden of over $ billion annually in direct costs that are estimated to increase to $ trillion by Disease modifying drugs that change the clinical course and de ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a cytokine release assay for the diagnosis of Lyme disease

    SBC: Biopeptides, Corp            Topic: NIAID

    Project Summary Lyme disease is a progressive disease that in later stages can lead to debilitating permanent damage to the nervous and musculoskeletal systems Early treatment with an appropriate course of antibiotics is highly effective at clearing infection and preventing disease progression Therefore early diagnosis is critical for ensuring patient outcome However most current IgM and I ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Aldosterone Synthase Inhibitor for CKD

    SBC: ANGION BIOMEDICA CORP.            Topic: 400

    DESCRIPTION provided by applicant The renin angiotensin aldosterone system RAAS plays a critical role in renal physiology Inhibitors of angiotensin converting enzyme ACE or angiotensin receptor blockers ARB are the mainstay in the clinical management of renal disorders such as chronic kidney disease CKD Despite initial success of ACE inhibition or ARB therapy patients often acquire r ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Primary Prevention of Sexual Violence among College Students

    SBC: NATIONAL HEALTH PROMOTION ASSOCIATES, INC            Topic: R44

    DESCRIPTION provided by applicant Primary Prevention of Sexual Violence among College Students This Fast Track SBIR proposal is designed to address the urgent need for an effective primary prevention approach to the problem of sexual violence among college students It is estimated that in every college women has been sexually assaulted while in college There is a dearth of primary preven ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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