Award Data

DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen to tissues. Increasing the bioavailability of NO should provide therapeutic benefit in the treatment of many diseases ascribed to insufficient NO bioavailability. A ...

DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. Current practice involves donor preconditioning to stabilize organs and tissues for transplant in attempts to increase the supply of donor organs acceptable for transpl ...

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I gran ...

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy to prevent or reduce ischemia-reperfusion injury during lung transplantation. The enzyme strongly preserves vascular integrity and inhibits platelet activation and aggregation without increasing bleeding risk. Using a protein informatics approach, we have successfully engineered an optimized human apyrase, APT ...

DESCRIPTION (provided by applicant): To increase the effectiveness of chronic disease prevention and health promotion interventions, researchers and practitioners must work collaboratively to ensure that evidence-based approaches are translated into publicly accessible tools and resources. To disseminate evidence-based intervention strategies, it is essential to summarize the associated processes, ...

DESCRIPTION (provided by applicant): Lung fibrosis, a group of incurable lung diseases with high mortality rates, is characterized by inflammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins (ECM) in lung parenchyma. Globally, five million people are affected by lung fibrosis. In the U.S. alone, 200,000 suffer from this disease. Of these m ...

DESCRIPTION (provided by applicant): Thromboembolic disorders are major causes of morbidity and mortality in the Western societies. Anticoagulants are pivotal agents in the prevention and treatment of arterial and venous thrombosis. The limitations of currently approved anticoagulant drugs have prompted the search for new anticoagulants with better pharmacological profiles. EVAS Therapeutics, LLC ...

Gnosys, the University of Alabama in Huntsville, and SAIC propose that entity level performance data be “rolled-up” into aggregate performance data and used to resolve unit level combat at the unit level. Such an approach for conducting aggregate simulation would realize the advantage of employing validated entity level data but also keep the advantages inherent in aggregate simulation of com ...

DESCRIPTION (provided by applicant): This grant will seek to develop a methodology that will allow us to test whether a promising new class of drugs for Alzheimer's disease is having the desired effect in the human brain. This methodology will allow pharmaceutical companies to make informed decisions about which drugs to advance into late stage clinical trials, and to optimize dosing and administr ...

DESCRIPTION (provided by applicant): Visualization of Medication Regimens to Improve Mental Health Care Iconic Health, LLC has conceptually developed Medication IconoGraphs, a patent pending set of visualization tools to assist mental health providers manage complex medication regimens. IconoGraphs display a patient's medication list to the prescriber in a novel way, conveying a wealth of clinical ...