Award Data

Check point screening of passengers is key to mitigating threats to aviation. This essential mission must be performed while expediting traffic flow and without discrimination to elderly or disabled travelers.The screening mission is challenged by the inaccessibility of Advanced Imaging Technology (AIT) and metal detector walk-through portals to travelers with mobility disabilities and certain med ...

Yotta Navigation proposes to develop a Mass Fatality Tracking System (MFTS) tagging device to aid search and recovery teams in locating victim remains during a Mass Casualty Incident (MCI). The Phase II effort will provide the DHS stakeholders with two sets of prototype Yotta Tag devices, complete with the supporting cloud-based database and User Interface (UI) applications. The first set of 10 pr ...

Many first responder organizations at various levels, including federal, state and local, as well as non-profit agencies each have different methods of identifying first responders on scene during an incident. The lack of an interoperable and standardized credentialing solution for first responders results in more challenges with communication and coordinated access to information on identificatio ...

Tiami LLC, a socially and economically disadvantaged small business located in a HUBZone, aims to develop a first-of-its-kind reduced-order modeling solution for data communications networks. We will develop a discrete-time linear time-invariant (LTI) state-space model for a general communications network. We will then apply projection methods such as proper orthogonal decomposition (POD) and bala ...

Project Summary / Abstract Chemotherapy induced peripheral neuropathy (CIPN) is a major side effect of oxaliplatin, a key drug in 1st line regimens for treating colorectal cancer. Dose-limiting CIPN prevents rt25% of patients from receiving full, maximally effective dose of oxaliplatin. In addition, 10-40% of patients receiving oxaliplatin-based therapy for colorectal cancer with develop chronic C ...

PROJECT SUMMARY/ABSTRACT The cysteine protease caspase-6 (Casp6) has been associated with neurodegenerative diseases for over fifteen years. In Alzheimer’s disease (AD), Casp6 is colocalized with amyloid plaques and tau tangles in human brain, and both human and animal model data indicate that activated Casp6 contributes to neuronal inflammation, neurodegeneration, and cleavage of proteins to to ...

Abstract This fast-track STTR application proposes to enhance, validate, and scale Sepsis Watch, a deep learning sepsis detection and management system built using data from the Emergency Department (ED) Duke University Hospital (DUH). The proposal will extend and enhance Sepsis Watch to EDs, general inpatient wards, and intensive care unit (ICU) settings across multiple health systems in the Unit ...

Cardiotoxicity is a leading cause of drug discovery attrition across all of preclinical and clinical drug discovery. While the FDA and the Comprehensive in vitro Proarrhythmia Assay initiative (CiPA) are focused primarily on predicting proarrhythmic effects, drug attrition due to cardiomyopathy, or primary cardiac cytotoxicity, may be even more prevalent, is typically currently only carried out vi ...

This project will achieve a computerized system that supplies digital content, both lexical and graphical, suitable for children, students and working adults of the Visually Impaired (VId) community, to increase their autonomy and potentiate their Quality of Life and societal contribution. While there is notable academic research, such as a high-density pin display tablet, there is no commercial, ...

PROJECT SUMMARY Radiation therapy is a widely used treatment modality for pelvic malignancies such as prostate and cervical cancer; however, the high doses needed to confer therapeutic benefit often inflict significant damage on the normal issue in and surrounding the radiation field. The most frequent complication of pelvic radiation is proctitis, which nearly all patients experience acutely and ...