Award Data

DESCRIPTION (provided by applicant)The major goals of this revised, SBIR Phase II application for the combined R25/R44 mechanism to complete development of a multi-media, cancer risk behavior modification intervention and to conduct a randomized controlled trial with low income patients and their primary care physicians to assess its impact. The prototype system of tools created in the Phase I is ...

DESCRIPTION (Provided by applicant): Hepatitis C virus (HCV) is the most prevalent chronic blood-borne infection in the U.S and a global health problem. Approximately 4 million individuals in the U.S. and 170 million individuals worldwide are chronically infected. As much as 40 percent of chronic liver disease is HCV related and this results in up to 10,000 deaths each year. Despite improvements, ...

"Fretting is a wear phenomenon that occurs between two mating surfaces: it is adhesive in nature, and vibration is its essential causative factor. Usually fretting is accompanied by corrosion. In general, fretting occurs between two tight fitting surfacesthat are subjected to a cyclic, relative motion of extremely small amplitude. Fretted regions are highly sensitive to fatigue cracking. Under fre ...

Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of vertebrates including hundreds that infect domesticated animals. Widespread use of drugs to control parasites ...

DESCRIPTION (provided by applicant): A hot start is beneficial or necessary for efficiency and reliability of a large portion of PCR reactions. The most demanding PCR reactions are especially dependent on a hot start. A heat switch can be added to PCR protocols by any of several manual or built-in methods, all of which have drawbacks, such as narrow conditions, extra expense, extra steps, prone to ...

"The proposed Phase 2 program focuses on the development of Powered Resonance Tube (PRT) actuators for application to Active Flow Control (AFC). For effective control across the full operating envelope of an air vehicle, high bandwidth and authority arerequired. In Phase 1, a new variable-frequency PRT actuator concept was developed and its feasibility was demonstrated. In Phase 2, the new actu ...

Because chondrocytes in culture are phenotypically unstable, techniques to grow tissue-engineered cartilage for the repair of injured or arthritic joints have met with limited success. Using human donor chondroctyes, we have developed an innovative method for producing what we call neocartilage, a viable, biomechanically stable tissue that we plan to commercialize for the repair of chondral defect ...

Incorporation of a new water-based sterol/stanol formulation system in foods and capsules lowers intestinal cholesterol absorption. This methodology is fat-free and provides a distinct improvement over existing inflexible oil-based strategies that increase the consumer's caloric load. A series of 14-week, double blind placebo controlled trials will examine the effect of fo ...

This new, reliable fastener will utilize the hole preparation designed for the existing fastener used in panels on the V-22 aircraft. It will utilize a retaining ring that allows positive captivation and holdout feature in the new stud assembly, whichwill solve the existing problem of stud retention and retraction. The nature of this new design will produce a rugged fastener that performs under ...

DESCRIPTION (provided by applicant): Male-to-female partner violence poses a major threat to the physical and emotional well being of women. Research assessing the efficacy of court-mandated domestic violence treatment programs has yielded disappointing results. A major problem with mandated treatment is that it tends to be standardized and 'one-size-fits-all,' neglecting individual differences in ...