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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Passive immunotherapy using plant-derived broadly HIV-1 neutralizing MAbs to prev

    SBC: Plant Vax, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): In the absence of specific intervention and with extended breast-feeding mother-to- child-transmission of HIV reaches a rate of ~35 % and infection of ~700,000 babies worldwide. Passive immunotherapy with a small numberof broadly neutralizing monoclonal antibodies (MAbs) in SHIV challenged macaques bodes well for the ability of infusion of neutralizing MAb to p ...

    SBIR Phase II 2011 Department of Health and Human Services
  2. Development of a low-cost hardware accelerator for 3D image registration

    SBC: IGI TECHNOLOGIES, INC            Topic: 102

    DESCRIPTION provided by applicant Our overall goal is to develop a novel computing solution for automatic and accurate registration spatial alignment of dimensional D medical images of any modality and any anatomy rigid or deformable in minute or less Such capability currently does not exist Existing image registration solutions have limited accuracy and or limited applicability p ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Attend BIO conference to meet with potential commercialization partners for ultra-fast MRI technology

    SBC: Weinberg Medical Physics, Inc.            Topic: NINDS

    DESCRIPTION provided by applicant This application represents a competing renewal request for a Phase II STTR project in which we constructed an ultra fast gradient system for magnetic resonance imaging Operation of the novel system is based upon the principle that the nervous system is relatively insensitive to very short exposures to changing magnetic fields As a result we are showing in ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  4. High Performance Signal Processing Tools with Fluctuation-Enhanced Sensing

    SBC: Signal Processing, Inc.            Topic: 9020163R

    We propose a high performance library of signal processing tools that incorporate a newly developed technique known as fluctuation enhanced sensing (FES) to enhance the novel microsensor developed at NIST. Our goal is to improve the performance of the NIST sensor from two angles. One is to apply our existing proven algorithms to the NIST data. The other one is to incorporate advanced FES concept t ...

    SBIR Phase I 2011 Department of CommerceNational Institute of Standards and Technology
  5. Enhanced Security Content Automation Protocol Editor

    SBC: G2, INC.            Topic: 9040577R

    G2 proposes to develop an intuitive, interactive SCAP content creation and editing utility that will provide a user-friendly operating environment. The promise of security automation offers the opportunity for great advances in software assurance, security governance/reporting, and ongoing monitoring activities. Hindering that promise is the fact that current data exchange protocols are cumbersome ...

    SBIR Phase I 2011 Department of CommerceNational Institute of Standards and Technology
  6. Multi-view, Photon Counting DXA Scanner for Quantitative Musculoskeletal Imaging

    SBC: QUANTUM MEDICAL METRICS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): The fragility of osteoporotic bones is largely due to alterations in the underlying structural geometry. Research has demonstrated that it is possible to measure the mechanical geometry of human bones in vivo using dualenergy x-ray absorptiometry (DXA) scans. However DXA scanners are designed to measure bone mineral density (BMD) and not structural geometry. Th ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Targeting host response to DAMP for therapy of Rheumatoid Arthritis

    SBC: Oncoimmune Inc            Topic: NIAMS

    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is among the most common autoimmune diseases. The current treatment for RA is mainly by targeting tumor-necrosis factor (TNF). Despite the remarkable efficacy, significant portion of RA patients are not responsive to this class of drugs. Therefore, there is an urgent need to develop therapeutic that can complement existing therapeutic ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Serum GP88 biomarker as a surrogate marker for disease progression in breast canc

    SBC: A&G PHARMACEUTICAL, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): 40,000 women die annually in the US as a result of breast cancer (BC). Although BC can be controlled if detected early, a significant number is not detected until later and these patients are treated using therapies tocontrol both primary tumor and micro-metastatic disease. Therapy response is monitored using imaging and clinical assessment. Failure to detect e ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Protease chain reactions for molecular analysis of cancer markers

    SBC: POTOMAC AFFINITY PROTEIN, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Our objective is to develop a protease chain reaction technology (ProCR) which will enable ultra- sensitive molecular detection. A protease chain reaction has four basic components: 1) a protease conjugated to a bindingmolecule, 2) an unconjugated protease, 3) an inhibitor protein which contains a proteolytic cleavage site and 4) a protease substrate which gene ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Multi-day Pain Management Therapy with Novel Injectable Formulation

    SBC: ORBIS BIOSCIENCES, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Our long term goal is to widespread the use of PPF technology for promoting effective production of drug-encapsulating microparticles with uniform size and physical characteristics that can be leveraged to release a specific drug at controlled rates over multi-day periods in vivo after a single administration. For this proposal, we are specifically targeting a ...

    SBIR Phase I 2011 Department of Health and Human Services

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