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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of an Acoustic Method for Rapid Assessment of Air Void System in Fresh Concrete

    SBC: DYNAFLOW, INC            Topic: 171FH2

    Air parameters such as specific surface (SS) and spacing factor (SF) are essential in evaluating Freeze-Thaw (F-T) durability in fresh concrete. Currently there is no method or device that can accurately meet such requirements. We propose to develop an acoustic air void measurement system that can be used in the field to measure in near real time air void distributions in fresh concrete. The propo ...

    SBIR Phase I 2017 Department of Transportation
  2. Basalt Fiber Reinforced Polymer for Railway Wood Ties Remanufacturing (BFRP-WTR)

    SBC: Intelligent Automation, Inc.            Topic: 171FR1

    The service life of the wood ties has been diminishing with increased axle loads with higher rail car speeds and frequencies. The depletion of wood and creosote induced contamination are of great environmental concerns. It is of a substantial interest to develop an effective recycling/remanufacturing methodology for creosote-treated wood ties. A composite wood tie design is proposed here, with use ...

    SBIR Phase I 2017 Department of Transportation
  3. Low Ground Clearance Vehicle Detection and Warning System

    SBC: Advanced Technology And Research Corporation            Topic: 131FR1

    Highway-rail grade crossings, at which there is an abrupt change in the level of the road surface as it crosses the tracks, present a severe hang-up risk to vehicles with low ground clearance. In Phase I and II, ATR developed a conceptual design for a Low Ground Clearance Vehicle Detection System (LGCVDS) to actively prevent such accidents. The LGCVDS is able to use a priori crossing profile data ...

    SBIR Phase II 2017 Department of Transportation
  4. Anxiety Coach for Children: A Tool to Increase Community and Educational Participation

    SBC: Minnesota HealthSolutions Corporation            Topic: NA

    This project develops a mobile device and/or web-based coaching tool that provides evidence-based therapeutic strategies for children with anxiety disorders with the goal to improve independence and participation in daily activities. Anxiety disorders are among the most common childhood mental health diagnoses with lifetime prevalence rates ranging from 15% to 20%. Additionally, anxiety disorders ...

    SBIR Phase I 2017 Department of Health and Human Services
  5. Digital Aided Descriptions (DAD): Encouraging Learning Among Children with Visual Disabilities Through Creativity and Dialogue

    SBC: Closed Caption Latina, Corporation            Topic: NA

    The goal of this project is to provide children with visual disabilities accessible technology that will enhance their community living and participation in an educational setting. The main objective is to give these children access to visual images through added description, while improving their literacy skills through a collaborative process with their peers without visual disabilities. The cus ...

    SBIR Phase I 2017 Department of Health and Human Services
  6. GENETIC CYTOLOGY FOR SURVEILLANCE OF RECURRENT BLADDER CANCER

    SBC: PAPGENE, INC.            Topic: NCI

    This proposal details the development of UroSeqS as a genetic cytology test to extend the utility of routinely collected urine specimens to the detection of recurrent bladder cancer UroSeqS is a genetic cytology assay that achieves sensitivity and specificity through identifying DNA mutations causative of cancer from routinely collected clinical specimens An innovative approach is used toanalyz ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A novel biomaterial based therapy utilizing auto antigen and adjuvant for the amelioration of Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Immune mediated diseases such as type diabetes T D multiple sclerosis rheumatoid arthritis and systemic lupus erythematosis are reaching epidemic proportions in the US T D affects an estimated million Americans with more than new patients diagnosed annually resulting in roughly $ B in health care costs in the US each year T D is an autoimmune disease characterized by effector ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Yeast based Immunotherapy against Clostridium difficile Infection

    SBC: FZATA INC            Topic: NIAID

    Abstract Antibacterial resistance is a global public health crisis Antibiotic resistant Clostridium difficile is responsible for more than deaths in US each year and the infection represents an urgent threat to public health worldwide Of most concern is that the incidence of C difficile infection CDI and disease severity is rapidly increasing in recent years due to the emergence of hy ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Evaluation of Natural Products and Derivatives as Antimalarial Agents

    SBC: Cascade Therapeutics, Inc.            Topic: NIAID

    PROJECT SUMMARY The proposed research focuses on the development of novel therapeutic agents for the treatment of malaria caused by P falciparum Preliminary studies have discovered some novel natural products and derivative molecules with potent in vitro activity against both sensitive and multidrug resistant malaria strains including the newly emerging artemisinin resistant parasite line New ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Strategies to Improve Production of a Full Length Native HIV Env Spike

    SBC: CODEX BIOSOLUTIONS            Topic: R

    Project Summary Production of HIV envelope protein Env trimeric gp cleaved to gp gp for clinical studies is a critical objective for vaccine development Its conformational plasticity which allows it to adopt multiple conformational states important for function often makes its expression and purification very difficult Our recent work shows a route for overcoming this probl ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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