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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Auto-antibody profiling of non-small cell lung cancer

    SBC: 20 20 Genesystems Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Tumor markers, measured in peripheral blood, could assist in diagnosis and management of non-small cell lung cancer (NSCLC) and potentially improve historically dismal outcomes. Circulating antibodies, generated to a wide range of tumor-associated proteins, can be translated into a valuable blood test for lung cancer. Preliminary data supports this hypothesis. ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Strategy for BIV Vector Site-Specific Integration

    SBC: ADVANCED VISION THERAPIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Lentivirus-based gene transfer systems represent a promising gene delivery technology, as they integrate into the genome of the target cell and mediate sustained expression of the transferred gene. To date, the majority of studies have used vectors based on the Human Immunodeficiency Virus (HIV), a human pathogen and the causative agent of AIDS. Advanced Vision ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel BIV vector pseudotyped with thogoto virus gp75

    SBC: ADVANCED VISION THERAPIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Lentivirus-based gene transfer systems represent a promising gene delivery technology, as they integrate into the genome of the target cell and mediate sustained expression of the transferred gene. Advanced Vision Therapies, Inc. (AVT) has developed a proprietary lentiviral vector system based on the bovine immunodeficiency virus (BIV), an animal lentivirus not ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Nisin as a decontaminant for B. anthracis spores on human skin

    SBC: AFG BIOSOLUTIONS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Project summary: An attack or terrorist event using spores of Bacillus anthracis continues to be an imminent threat. In the event of such an attack, many surfaces including human skin will become contaminated with disseminated spores. Spores carried on human skin not only pose the threat of developing into cutaneous anthrax, but can also be carried to other loc ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. Microfluidic Controlled Gel-Drop Microarrays for Biothreat Diagnostic Devices

    SBC: AKONNI BIOSYSTEMS INC            Topic: N/A

    DESCRIPTION (provided by applicant): Whether in clinical or epidemiological settings, there is a continued need in identification of B. anthracis and unambiguous discrimination it from close relatives and organisms with similar characteristics. Genomic analysis provides direct information about tested organism in opposite to indirect, phenotype analysis, however represents in current certified Ant ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Oral Formulation of Zonulin Antagonist AT-1001 for Diabe

    SBC: ALBA THERAPEUTICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The trigger for autoimmune destruction of pancreatic beta cells in Type 1 diabetes (T1D) is unclear. Evidence exists for the role of increased intestinal permeability, secondary to intestinal tight junctions (tj) disassembly, in the pathogenesis of various autoimmune diseases including T1 D. Over the last decade our studies have focused on the mechanism(s) of a ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Modified Diphtheria Toxin IL-7 Fusion Toxins

    SBC: ANJIN GROUP, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Sweeney et al. (1998) originally reported the construction of DAB389IL-7, a fusion protein based on diphtheria toxin (DT), and proposed that this fusion protein could be employed as a therapeutic agent for hematological malignancies, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia and Sezary syndrome. Studies by ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. Therapeutic Robot to Teach Social Skills to Primary School Children with ASD

    SBC: Anthrotronix, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This project is part of a long-term effort to reduce the burdens and disability associated with Autism Spectrum Disorders (ASD). The majority of adults and adolescents who have an ASD diagnosis do not have mental retardation, and are notable for their language abilities, which in many cases appear intact. Nevertheless these individuals fail to achieve vocationa ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. FPRL1-specific anti-inflammatory compounds: Alzheimer's

    SBC: APPLIED CELL SCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this project is to develop an antagonist for the G-protein-coupled receptor FPRL1 (formyl peptide receptor-like 1) to test the hypothesis that blocking this receptor will prevent accumulation of inflammatory cells into plaques in Alzheimers disease, and thereby prevent neuronal degeneration. FPRL1 receptors have been shown to be express ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. MobileReminder: A Camera Phone Based Medication Reminder for Older Patients

    SBC: APPLIED MEDIA ANALYSIS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Non-adherence to medication is one of the most serious problems facing health care today. Older patients often find it difficult to remember when to take which medication, and in what quantities. Since older individuals are more disposed to memory loss, confusion, visual impairment, and adverse drug reactions, ensuring proper medication is a challenging goal. A ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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