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THE ADVENT OF NEW TECHNIQUES AND MODERN EQUIPMENT FOR NUCLEAR MAGNETIC RESONANCE (NMR) RESEARCH MAKES NMR THE METHOD OF CHOICE FOR STUDYING THE STRUCTURE AND DYNAMICS OF BIOLOGICAL MOLECULES IN SOLUTION. MODERN NMR EXPERIMENTS CAN YIELD A STAGGERING AMOUNT OF STRUCTURAL INFORMATION, WHICH MAKES THE TECHNIQUE VERY ATTRACTIVE BUT LEADS TO PROBLEMS PROCESSING THE DATA. SINCE NMR SPECTROMETERS ARE VER ...

THE PRESENT PROCESS OF PRODUCING INTERMETALLIC ALLOY POWDER BY MELTING, CASTING, AND A POWDER ATOMIZA- TION STEP IS EXPENSIVE AND TECHNICALLY LACKING, THUS LIMITING THE ULTIMATE MECHANICAL AND PHYSICAL PRO- PERTIES OF THE INTERMETALLIC MATERIAL. THIS PROJECT EX- AMINES THE FEASIBILITY OF PRODUCING NICKEL AND TITA- NIUM ALUMINIDE INTERMETALLIC ALLOY POWDER BY THE DIRECT REDUCTION OF METAL CHLORIDE ...

THE PURPOSE OF THIS CONTRACT PROPOSAL IS TO DEVELOP NEW RADIOIODINE-LABELED CONJUGATES FOR MONOCLONAL ANTIBODIES THAT CAN BE USED IN DIAGNOSIS AND THERAPY OF CANCER. THE GOAL OF OUR PROPOSED RESEARCH IS TO INVESTIGATE A NOVEL METHOD OF INTRODUCING HIGH SPECIFIC ACTIVITY RADIOIODINE INTO SOME SMALL MOLECULES WHICH CAN BE CONJUGATED TO MONOCLONAL ANTIBODIES. OUR APPROACH TO DEVELOP NEW CONJUGATES IS ...

THE OBJECTIVE OF THIS PHASE I SBIR PROJECT IS TO DEVELOP A RE-186 AGENT SUITABLE FOR LABELING BIFUNCTIONAL CHELATING AGENT ANTIBODY CONJUGATES. ALTHOUGH CHEMICALLY SIMILAR TO TC-99M, APPLICATION OF RE-186 TO YIELD POTENTIAL THERAPEUTIC RADIOPHARMACEUTICALS PRESENTS PROBLEMS WHICH HAVE YET TO BE SOLVED. SPECIFICALLY, IT IS MUCH MORE DIFFICULT TO MAINTAIN RE IN REDUCED OXIDATION STATES THAN TC, AND ...

SAILCOMP INDUSTRIES PROPOSES TO DESIGN AN ACOUSTIC DOPPLER WIND VELOCITY AND DIRECTION SENSING SYSTEM THAT OVERCOMES THE PROBLEM ASSOCIATED WITH PRESENT MECHANICAL DESIGNS. THE ACOUSTIC VELOCIMETER SYSTEM WILL CONSIST OF FOUR PAIRS OF TRANSDUCERS IN FEEDBACK LOOPS. BY MEASURING THE DOPPLER PHASE SHIFT IN EACH OF THE FOUR LEGS OF THE SYSTEM, WIND VELOCITY AND DIRECTION CAN BE CALCULATED. THIS SOLID ...

THE NEED EXISTS FOR AN ADVANCEMENT IN EXPLOSIVE EXCAVATION METHODS TO IMPROVE THE EXISTING CYCLIC PROCESS. PHASE I OF THIS PROJECT WILL PROVE FEASIBILITY OF AN INNOVATIVE EXPLOSIVES EXCAVATION SYSTEM WHICH WILL COMBINE THE AUTOMATION OF TUNNEL BORING MACHINES WITH THE LOW ENERGY AND FLEXIBILITY OF EXPLOSIVES. THE SYSTEM WILL INCLUDE A CONTINUOUS, CONCURRENT CYCLE OF DRILLING LOADING, BLASTING AND ...

THE HARD-COPY FETAL MONITOR RECORD (FMR) PRODUCED AND ANNOTATED DURING LABOR CONTAINS THE HISTORY OF THE LABOR AND IS PART OF THE PATIENTS RECORD. THE BULK AND FORM OF THE FMR IS UNACCEPTABLE FOR THE CHART, THE MEDICAL RECORDS SYSTEM, OR LONG-TERM RETENTION: ALL ARE CRITICAL TO PATIENT MANAGEMENT AS WELL AS DOCUMENTATION OF CARE PROVIDED. MICROFILMING IS EXPENSIVE, TIME CONSUMING, AND MUST BE CARE ...

WE PROPOSE TO DEVELOP THE APPLICATION OF NEW TWO DIMENSIONAL, STATE OF THE ART CHARGE COUPLED DEVICE (CCD) IMAGE DETECTORS TO THE PROBLEM OF ANALYSIS OF PROTEINS BY DIGITIZATION OF TWO DIMENSIONAL POLYACRYLAMIDE ELECTROPHORETIC GELS. LONG TERM SUCCESS OF THIS PROJECT WILL RESULT IN COMMERCIALIZATION OF A NEW PRODUCT LINE OF MEDICAL MACHINERY, MORE WIDESPREAD USE OF ELECTROPHORESIS IN A CLINICAL SE ...

CRYOCOOLERS AND GAS LIQUEFIERS UTILIZE ISENTHALPIC EXPANSION OF COOLED GAS IN JOULE-THOMSON NOZZLES. TO EFFECTIVELY OPTIMIZE USAGE OF THE COMPRESSED GAS, A VARIABLE GAS MASS FLOW RATE IS NECESSARY. A HIGH FLOW RATE IS REQUIRED INITIALLY WITH A PROGRESSIVE REDUCTION AS THE DESIGN CONDITION IS ATTAINED AND INTERMITTENT FLOW THEREAFTER DEPENDING ON THE LOAD DEMAND. THIS PROJECT INCORPORATES INNOVATIV ...

LARGE-GRAIN MATERIALS ARE DIFFICULT TO INSPECT WITH CONVENTIONAL ULTRASONIC NONDESTRUCTIVE EVALUATION (NDE) METHODS. THIS IS PARTICULARLY TRUE OF THE CEN- TRIFUGALLY CAST STAINLESS STEEL USED FOR COOLANT PIPING IN PRESSURIZED WATER REACTORS (PWR). REDUCED TEST FREQUENCIES MUST BE USED TO PENETRATE THE MATERIAL. HOWEVER, A CORRESPONDING DECREASE IN NEAR-SURFACE RESOLUTION IS INCURRED RESULTING IN A ...