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THE ADVENT OF NEW TECHNIQUES AND MODERN EQUIPMENT FOR NUCLEAR MAGNETIC RESONANCE (NMR) RESEARCH MAKES NMR THE METHOD OF CHOICE FOR STUDYING THE STRUCTURE AND DYNAMICS OF BIOLOGICAL MOLECULES IN SOLUTION. MODERN NMR EXPERIMENTS CAN YIELD A STAGGERING AMOUNT OF STRUCTURAL INFORMATION, WHICH MAKES THE TECHNIQUE VERY ATTRACTIVE BUT LEADS TO PROBLEMS PROCESSING THE DATA. SINCE NMR SPECTROMETERS ARE VER ...

THE PRESENT PROCESS OF PRODUCING INTERMETALLIC ALLOY POWDER BY MELTING, CASTING, AND A POWDER ATOMIZA- TION STEP IS EXPENSIVE AND TECHNICALLY LACKING, THUS LIMITING THE ULTIMATE MECHANICAL AND PHYSICAL PRO- PERTIES OF THE INTERMETALLIC MATERIAL. THIS PROJECT EX- AMINES THE FEASIBILITY OF PRODUCING NICKEL AND TITA- NIUM ALUMINIDE INTERMETALLIC ALLOY POWDER BY THE DIRECT REDUCTION OF METAL CHLORIDE ...

THE PURPOSE OF THIS CONTRACT PROPOSAL IS TO DEVELOP NEW RADIOIODINE-LABELED CONJUGATES FOR MONOCLONAL ANTIBODIES THAT CAN BE USED IN DIAGNOSIS AND THERAPY OF CANCER. THE GOAL OF OUR PROPOSED RESEARCH IS TO INVESTIGATE A NOVEL METHOD OF INTRODUCING HIGH SPECIFIC ACTIVITY RADIOIODINE INTO SOME SMALL MOLECULES WHICH CAN BE CONJUGATED TO MONOCLONAL ANTIBODIES. OUR APPROACH TO DEVELOP NEW CONJUGATES IS ...

THE OBJECTIVE OF THIS PHASE I SBIR PROJECT IS TO DEVELOP A RE-186 AGENT SUITABLE FOR LABELING BIFUNCTIONAL CHELATING AGENT ANTIBODY CONJUGATES. ALTHOUGH CHEMICALLY SIMILAR TO TC-99M, APPLICATION OF RE-186 TO YIELD POTENTIAL THERAPEUTIC RADIOPHARMACEUTICALS PRESENTS PROBLEMS WHICH HAVE YET TO BE SOLVED. SPECIFICALLY, IT IS MUCH MORE DIFFICULT TO MAINTAIN RE IN REDUCED OXIDATION STATES THAN TC, AND ...

SAILCOMP INDUSTRIES PROPOSES TO DESIGN AN ACOUSTIC DOPPLER WIND VELOCITY AND DIRECTION SENSING SYSTEM THAT OVERCOMES THE PROBLEM ASSOCIATED WITH PRESENT MECHANICAL DESIGNS. THE ACOUSTIC VELOCIMETER SYSTEM WILL CONSIST OF FOUR PAIRS OF TRANSDUCERS IN FEEDBACK LOOPS. BY MEASURING THE DOPPLER PHASE SHIFT IN EACH OF THE FOUR LEGS OF THE SYSTEM, WIND VELOCITY AND DIRECTION CAN BE CALCULATED. THIS SOLID ...

THE NEED EXISTS FOR AN ADVANCEMENT IN EXPLOSIVE EXCAVATION METHODS TO IMPROVE THE EXISTING CYCLIC PROCESS. PHASE I OF THIS PROJECT WILL PROVE FEASIBILITY OF AN INNOVATIVE EXPLOSIVES EXCAVATION SYSTEM WHICH WILL COMBINE THE AUTOMATION OF TUNNEL BORING MACHINES WITH THE LOW ENERGY AND FLEXIBILITY OF EXPLOSIVES. THE SYSTEM WILL INCLUDE A CONTINUOUS, CONCURRENT CYCLE OF DRILLING LOADING, BLASTING AND ...

THE POSSIBILITY OF NONINVASIVE BIOCHEMICAL ANALYSIS PROVIDED BY THE MEASUREMENT OF SPECTRA OF PHOSPHOROUS AND OTHER NUCLEI HAS MOTIVATED THE INCREASING USE OF HIGH FIELD SUPERCONDUCTING MAGNETS IN MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS. A LARGE FRACTION OF THE OPERATING COST OF A SUPERCONDUCTING MRI SYSTEM IS ASSOCIATED WITH THE CRYOSTAT DESIGN AND THE CONSUMPTION OF CRYOGENS USED TO COOL THE MA ...

CREARE WILL EVALUATE THE AKL REPRESENTATION, FROM AUDITORY MODELING AND SPEECH RECOGNITION RESEARCH, FOR APPLICATION TO TACTILE AIDS FOR THE DEAF. THE REPRESENTATION IS CHARACTERIZED BY A SMALL NUMBER OF INFORMATION CHANNELS WHICH ARE STATISTICALLY OPTIMIZED FOR REPRESENTING SPEECH. IN PHASE I WE WILL USE COMPUTER MODELING AND NUMERICAL METHODS TO EVALUATE THE EFFECTIVENESS OF THE NEW REPRESENTATI ...

TURBOEXPANDERS WHICH OPERATE IN GAS BEARINGS ARE FREQUENTLY USED IN LABORATORY SIZE HELIUM LIQUIFIERS AND REFRIGERTORS WHERE EXTENDED OPERATION WITHOUT MAINTENANCE IS DESIRED. UNFORTUNATELY, CRYOGENIC SYSTEMS EMPLOYING THESE EXPANDERS ARE SUBJECT TO START-UP AND SHUT-DOWN TRANSIENTS AND TO SYSTEM UPSETS WHERE SYSTEM PRESSURES MAY CHANGE SUBSTANTIALLY. UNDER SUCH CIRCUMSTANCES, BEARING FAILURES CAN ...

THERE IS A STRONG NEED FOR SIMPLE, RELIABLE CLOSED-CYCLE CRYOCOOLERS CAPABLE OF PROVIDING APPROXIMATELY 5 WATTS OF REFRIGERATION AT TEMPERATURES NEAR 65-75 K. THE MOST PROMINENT EXAMPLE OF CURRENT APPROACHES IS THE LINEAR STIRLING CYCLE UNDER SPONSORSHIP OF NASA. RECENT TECHNOLOGICAL DEVELOPMENTS IN THE MINIATURIZATION OF GAS BEARINGS AND TURBINES INDICATE THAT A REVERSE-BRAYTON CYCLE USING TURBOM ...