Award Data

Glioblastoma multiforme (GBM) is a malignant primary brain tumor affecting about 12,000 new cases per year in the U.S. Average survival is only about 14-15 months. Radiation (RT) is most commonly administered as 30 fractions of 2 Gray each over 6-weeks with concomitant temozolomide (TMZ). GBM tumors are hypoxic. The primary mechanism of RT is creation of singlet oxygen; hypoxia within GBM adversel ...

DESCRIPTION provided by applicant Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA matched sibling or unrelated donor Transplants using stem cells from umbilical cord blood provide an alternative for these patients allowing transplantation to proceed with less stringent HLA matching requirements Unfortunately in addition to t ...

DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

This Small Business Innovation Research Phase I project will support the development of a confocal optical microscope with two-dimensional topographical profiling and multiple spectroscopic modes in a single, affordable precision instrument. The system will make a major impact in the $6.2 billion microscope market, with a near-term market penetration potential of over 5%, and significant growth po ...

The broader impact/commercial potential of this project is the reduction in the cost of renewable energy. The dramatic decline in the cost of wind energy over the last several decades has been fueled by the ever increasing turbine size and the introduction of new manufacturing methods and materials. However, the industry is approaching the limits of this trend due to the increased wear and tear of ...

This SBIR Phase I project will address drug resistance in cancer patients through the advanced analysis of biopsies. Not only is each patient unique but their tumor contains a high level of genetic diversity as well. Overlooked diversity within patient tumors can lead to inadequate treatment and consequently acquired drug resistance, and has also been shown to predict therapeutic response to certa ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to revolutionize the way that woven textiles are designed and manufactured. The textile industry is currently organized around fixed catalogs of fabrics, with significant barriers to the introduction of new products, including limited access to industrial equipment. The project will create ...

This SBIR Phase I project seeks to develop a novel low-cost molecular filter for use in harsh environments. This is accomplished using commodity silica gel, commonly found as a desiccant in food packing, whose pores can be made to be only a few molecules wide. Accurate tuning of the size and shape of the silica gel pores enables certain molecules to pass through while others are block from passing ...

The broader impact/commercial potential of this Small Business Innovation Research Phase I project includes the development of new methods to biodegrade waste plastics. Plastic waste is an significant environmental burden. Over 300 million tons of plastic are used each year, resulting in millions of tons of persistent plastic waste, some of which can take up to 600 years to degrade. Mealworms (Ten ...

This project will develop an immersive and dynamic multi-player game that addresses a pressing need to provide engaging technologies that prepare students to apply collaborative, cross-disciplinary scientific practices to global societal challenges. In an augmented classroom with their real life peers, students must establish a colony on Mars that is capable of sustaining thousands of refugees fro ...