Award Data

Glioblastoma multiforme (GBM) is a malignant primary brain tumor affecting about 12,000 new cases per year in the U.S. Average survival is only about 14-15 months. Radiation (RT) is most commonly administered as 30 fractions of 2 Gray each over 6-weeks with concomitant temozolomide (TMZ). GBM tumors are hypoxic. The primary mechanism of RT is creation of singlet oxygen; hypoxia within GBM adversel ...

DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

The broader impact/commercial potential of this project is the reduction in the cost of renewable energy. The dramatic decline in the cost of wind energy over the last several decades has been fueled by the ever increasing turbine size and the introduction of new manufacturing methods and materials. However, the industry is approaching the limits of this trend due to the increased wear and tear of ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of software that automatically identifies and labels problems that patients encounter when they receive care. This information tells health care providers exactly what they need to fix to improve patient care. Applications of the software include: a) the developing different ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project will be the expansion of the range of applications of safe, selective, and effective ribonuclic acid interference (RNAi) triggers for use as pesticides. If successful, this biotechnology will contribute to sustainable food production and enhance biodiversity with minimal use of non-selective pesticide ...

This SBIR Phase I project will address drug resistance in cancer patients through the advanced analysis of biopsies. Not only is each patient unique but their tumor contains a high level of genetic diversity as well. Overlooked diversity within patient tumors can lead to inadequate treatment and consequently acquired drug resistance, and has also been shown to predict therapeutic response to certa ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will not only produce a multifunctional thermal insulation structure that is easy to install onto any existing single-, double-, or even triple-pane windows in reducing total building energy consumption, but also improve water condensation issues and occupant discomfort that are associated wit ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to revolutionize the way that woven textiles are designed and manufactured. The textile industry is currently organized around fixed catalogs of fabrics, with significant barriers to the introduction of new products, including limited access to industrial equipment. The project will create ...

This Small Business Innovation Research Phase I project will enable video-rate three-dimensional (3D) imaging within two-photon microscopes (TPMs) through the use of an electrostatically actuated deformable membrane mirror (DMM). As a subset of laser scanning microscopes (LSMs), TPMs achieve very high spatial resolution by using a focused, high-power laser beam to excite fluorescence via the simul ...

The broader impact/commercial potential of this project is that the proposed system will enhance the ability of the 1.3 million people currently living in the United States with a lower limb amputation to walk in unconstrained environments. The proposed Quasi-Active Prosthetic Ankle System (QPAS) addresses the RH6: Human Assistive Technologies area. QPAS will be lightweight, have a long battery li ...