Award Data

Pancreatic ductal adenocarcinomaPDACis a highly lethal form of cancerIn most patientsdetection is at an advanced stage and the outcome is poorThis project is directed towards development of a molecularly targeted ultrasound contrast agent with potential to detect early stage disease while still curableIn Phase I of this projectwe incorporated the engineered human single chain variable fragmentscFv ...

Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

Project Summary/Abstract The proposed work is directed at the commercialization of BMSEEDandapos;s Micro-Electrode Array Stretching Stimulating und Recording Equipment (MEASSuRE) technology. MEASSuRE bridges the gap between in vitro and in vivo research by simulating the biomechanical and electrical environment of cells in the body in a controlled environment outside of the body. The applications ...

During this SBIR program, Control Vision, Inc. will develop an innovative sub-scale Fly Along Sensor Package (sFASP) which will be deployed from a Ballistic Missile Defense System flight test target AO deployment canister. This sFASP will give unprecedented sensor visibility into Ballistic Missile Defense System test scenes providing truth data to the many different areas of Missile Defense. Appro ...

Project Summary The long term goal of this Phase II SBIR project is to develop a commercially viable ultrasound contrast reagentUCRthat will allow the noninvasive identification and treatment of newly forming abdominal adhesions after surgerySuccessful implementation would have significant impact because we would both improve patient post surgical monitoring and considerably reduce the cost of adh ...

Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

A system to covertly communicate in underwater acoustic shallow water environment for Naval applications is described. Techniques for clandescent and directional communication are evaluated. Broadband underwater communications are developed.

PROJECT SUMMARY The absence of safe and effective strategies for the management of ocular pain is motivating the development of a novel topical drug suitable for patient self administrationConventional local anestheticssuch as proparacaineinhibit voltage gated Naion channelsNaVand are highly effective for the management of ocular pain in acutein office settingsHoweverthese agents are short acting ...

NODA Telehealth system improves access to an autism diagnostic assessment by guiding families to share video clips of their child at homeso diagnostic clinicians can directly observe andtagvideo of any atypical behaviorand if warrantedrender a diagnosisThis system is evidence based and has been commercializedwith several published studies to discuss the benefitsWe now propose to improve this servi ...

Several high energy physics experiments require accurate timing measurements and transient digitization at high sampling rates, equaling or exceeding 5 gigasamples per second (GSPS). To date, only a few transient digitizer chips have been developed for this purpose and they are based on storing the analog samples onto long buffers from which they are digitized with low-rate analog-to-digital conve ...