Award Data

Glioblastoma multiforme (GBM) is a malignant primary brain tumor affecting about 12,000 new cases per year in the U.S. Average survival is only about 14-15 months. Radiation (RT) is most commonly administered as 30 fractions of 2 Gray each over 6-weeks with concomitant temozolomide (TMZ). GBM tumors are hypoxic. The primary mechanism of RT is creation of singlet oxygen; hypoxia within GBM adversel ...

DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

Protein kinases are central players in almost every aspect of human physiology and serve as critical mediators of signal transductionThe dysfunction of many kinases is implicated in cancerdiabetesinflammationand cardiovascular diseases and many are validated targets for therapeutic interventionThe human genome encodesprotein kinasesYettheor so marketed protein kinase drugstarget only a small fract ...

PROJECT SUMMARYThe goal of this project is to develop a novel vaginal contraceptive gel product containing PPCM sodium saltPPCMPPCM is a novel polymer drug that inhibits infection of HSVHIVNgonorrhea and is also contraceptiveThis novel drug has an average molecular weight ofis designed to be used topicallyand thus far passed all safety studies and does not appear to be systemically absorbedPPCM ha ...

DESCRIPTIONprovided by applicantMass spectrometryMSis the "gold standard" for chemical analysis and has been widely applied due to its high sensitivityhigh specificity as wellas high quantitation precisionTraditional chemical analysis using MS requires complex proceduresincluding multiple steps for sample preparationchromatographic separationMS analysis and data analysisEquipment typically require ...

Neonatal hypoxia ischemiaHIremains a major cause of acute perinatal brain injuryleading ultimately to neurologic dysfunction manifesting as cerebral palsymental retardationand epilepsyUnfortunatelycurrent treatment and prevention strategies in newborns are limitedThere are no currently available therapies to prevent treat and or attenuate brain damage in premature infants other than supportive car ...

Project Summary The present applicationNovel Treatment for Posttraumatic Stress Disorderaddresses the critical need for more efficacious treatments for posttraumatic stress disorderPTSDThe excitatory neurotransmitterglutamateactivates a key neural signaling cascade upon a trauma experienceIn this activationglutamate binds to and activates the NMDA receptora glutamate receptor subtypeBinding and ac ...

SAMPLE PREPARATIONThe Achilles Heel of Mass Spectrometry Based Diagnostics IIProject SummaryLC MS provides superior data in clinical diagnostics relative to immunoassaysbut it is slow and costlyAs the old saying goestime is moneyThe technique must become simplerfasterand less expensive to displace olderless accurate immunological assayIAmethodsThe focus of this proposal is to make LC MS analytics ...

Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

Project Summary Abstract Lung cancer remains the leading cause of cancer related deaths worldwideSurgical removal of the tumor is the best therapeutic options for patients with non small cell lung canceryet up toof patients still leave the operating room with deposits of cancer left behindAdvances in CAT and PET scans have provided surgeons with helpful radiographic imaging information prior to su ...