Award Data

DESCRIPTION (provided by applicant): The overall goal of the proposed SBIR program is to implement and evaluate a low cost retinal camera, the Laser Scanning Digital Camera (LSDC), in a system for diabetic retinopathy (DR) screening. Untreated DR has reached epidemic levels in underserved populations worldwide. As the LSDC has already demonstrated its readiness for DR screening in preliminary stud ...

DESCRIPTION (provided by applicant): We propose to develop NeuroAutomatica, an innovative, automated neuron reconstruction software platform that provides analysis tools for automated quantitative analysis of neuronal structure. The software will provide multi-scalar information about multiple individual neurons in close proximity, including dendritic spines. Providing this innovative functionalit ...

DESCRIPTION (provided by applicant): We propose a commercial product composed of a computerized microscope system that allows investigators to perform automated, quantitative analyses of locomotory and other complex behaviors of freely moving C. elegans nematodes. Using the soil nematode, C. elegans, as a practical and efficient model in toxicology studies requires creation of automated technologi ...

DESCRIPTION (provided by applicant): A fast, cost-effective multispectral confocal imaging capability for high-resolution mapping in vivo will be created during this project. This new approach will be based on fiber Bragg gratings, a technology not utilized previously in biomedical imaging, and will ultimately enable the early in vivo detection and treatment of cancer at the cellular level. The c ...

DESCRIPTION (provided by applicant): A clear need exists for the development of advanced power ources and recharging options for implanted electro-medical devices. The useful lifetime of most implants is constrained by the longevity of the power source. When an implanted primary (non-rechargeable) battery has discharged to a predetermined threshold, surgery must be scheduled to replace the battery ...

DESCRIPTION (provided by applicant): The ultimate goal of this SBIR project is to develop a novel proteomic system that will enable the real- time expression profiling of proteins in live murine embryonic stem (mES) cells and in differentiated cells derived there from. The first step involves the establishment of a library of fluorescent trap mES cell lines, each of which will harbor a single fluo ...

DESCRIPTION (provided by applicant): Pregnant women, particularly those from underserved populations, often have a multitude of behavioral risks that threaten positive pregnancy and birth outcomes, as well as the future health of mother and baby. This application represents innovative research for impacting the promotion of healthy behaviors among pregnant women. The objective is to develop and te ...

DESCRIPTION (provided by applicant): The long term goal of this project is to develop a biomarker - the Needle Torque Test (NTT) - capable of detecting connective tissue abnormalities associated with musculoskeletal disorders. The NTT is administered by inserting an acupuncture needle into connective tissue and using the Automated Needle Torque Sensor to deliver a precise biomechanical stimulus to ...

DESCRIPTION (provided by applicant): The goal of this project is to develop an automated respiratory rate monitor that is economical, easy to use, accurate and widely accessible. The motivation for this project is well documented findings that respiratory rates are not accurately measured in many medical settings, such as, emergency rooms and general hospital wards. The respiratory rate is a core ...

THE OBJECTIVE OF THIS RESEARCH PROJECT IS TO PRODUCE A PORTABLE, MINIATURIZED DIALYSIS MACHINE WHICH IS SIMPLE, SAFE, AND SYMPTOM-FREE IN OPERATION. THIS DIALYSIS MACHINE SHOULD ALLOW THE AVERAGE HEMO-OR PERITONEAL DIALYSIS PATIENT TO PERFORM DIALYSIS BY HIMSELF AT HOME, UNASSISTED. THE MACHINE WILL BE SMALL (12 LBS.), PORTABLE, AND TOTALLY SELF-CONTAINED (WITHOUT NEED FOR CONNECTION TO WATER SUPP ...