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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Optimum Control of Induction Generators for Water Current Energy Harnessing

    SBC: Electro Standards Laboratory, Inc.            Topic: 815

    Optimization of generator performance and maximization of output power are difficult to attain in the generation of hydro-power. This is due to the changing water conditions and corresponding changes in the form of available energy. ESL proposes to use self-tuning controls in combination with a suitably chosen and optimized generator driven by hydro-energy and condition it for distributi ...

    SBIR Phase I 2010 Department of Commerce
  2. Scaffolding for Math Games

    SBC: Virtual Learning Technologies (Sokikom)            Topic: N/A

    In 2009, Virtual Learning Technologies received an award to develop Frachine, a web-based single player fraction learning game for elementary school students. This project will develop an intelligent tutoring system that will integrate with the existing game to provide the individualized instructional support required to further improve student math outcomes.  Phase I will develop a prototype ...

    SBIR Phase I 2010 Department of Education
  3. A NEW BIOSENSOR BASED ON CATASTROPHIC PROTEIN CHANGES

    SBC: ATERIS Technologies            Topic: NIEHS

    DESCRIPTION (provided by applicant): This Phase I project will test the idea that mechanostress-sensitive, fluorescent polymers can detect structural changes induced in proteins following reaction of the protein with small molecule inhibitors. This concept will be tested and proven using recombinant acetylcholinesterase (AChE) an enzyme that is known to undergo catastrophic denaturation when it re ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Nuclease Probe Mediated Sequencing

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): Sequencing is very powerful for identifying differences in genomic DNA that may regulate cell function and diseases, pre-dispose persons to certain diseases, or warn of adverse drug metabolism. It provides a basis for identifying differences in gene expression, though such applications have been limited and are problematic because each expressed gene can vary f ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Not Available

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NIEHS

    This Phase I proposal will develop and validate assays to measure the metabolism of compounds and their affect on liver cells using a multiplexed gene expression assay platform, the quantitative Nuclease Protection Assay (qNAP¿) that can measure the expression of up to 100 mRNA and miRNA and is a simple, robust and highly precise assay that provides high sample throughput. Two cell systems wil ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Not Available

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NCI

    A molecular test using FFPE tissue from patients to distinguish basal-like breast cancer from other subtypes will be developed and confirmed. The test will be based on a commercial platform, the lysis-on ly quantitative Nuclease Protection Assay (qNPA 1M). Current gene expression signatures described for breast cancer, in particular those for distinguishing basal-like breast cancer from other subt ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Screening Test for HPV+ Head and Neck Cancer

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): There is currently no good way to screen for early stages of head and neck cancers caused by high risk types of human papillomavirus. The objective of this proposal is to develop a screening assay for dental patients to detect HPV+ head and neck cancer ( HNC ) pre-symptomatically, based on the use of viral and host gene biomarkers. The overall hypothesis of thi ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Prevention of ischemia reperfusion injury associated with acute myocardial infarc

    SBC: HOPE PHARMACEUTICALS            Topic: NHLBI

    DESCRIPTION (provided by applicant): Hope Pharmaceuticals is a small business that distributes Sodium Nitrite Injection and owns patent rights to a recently discovered use for sodium nitrite as a means to prevent ischemia-reperfusion injury. Ischemia-reperfusion injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischemia. The absence of oxygen and othe ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Independent delivery of software-enhanced speech therapy for Parkinson disease

    SBC: LSVT GLOBAL, LLC            Topic: NIDCD

    DESCRIPTION (provided by applicant): Independent access to efficacious voice treatment (LSVT LOUD) through technology is an essential solution to improving quality of life in individuals with PD. It can alleviate the barrier of inadequate numbers of clinicians, enhance feasibility of the essential intensive dose requirements, while relieving the physical burden of traveling to and from the clinic. ...

    SBIR Phase I 2010 Department of Health and Human Services
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