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THE LONG-TERM OBJECTIVE OF THE RESEARCH IS TO MAKE AVAILABLEAT MODEST COST A DEVICE TO PROVIDE THE BENEFITS OF PORTABLE METERED-DOSE INHALANTS TO CHILDREN AND ADULTS WHOSE POOR COORDINATION OR PHYSICAL LIMITATIONS NOW PRECLUDE THEIR USE.THE SPECIFIC AIMS OF THIS PHASE I RESEARCH INCLUDE COMPLE- TION OF THE DESIGN OF THE DEVICE REFERRED TO AS THE BREATH- ACTIVATED MEDICATION SPRAY (BAMS) DISPENSER, ...

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A PILOT SERIES OF THREE COMPUTER-INTERACTIVE VIDEODISK (CIVD) MODULES WILL BE DEVELOPED FOR TEACHING TOPICS IN TRANSFUSION MEDICINE (TM). THE CONTENT OF THE CIVD MODULES IS DETERMINED FROM THE NHLBI NATIONAL TM CURRICULUM AND INCORPORATES BOTH THE ETHICAL AND PSYCHOSOCIAL ISSUES INVOLVED IN THE PRACTICE OF TM. THE AUDIOVISUAL ELEMENT OF THE CIVD PACKAGES WILL BE SUPPLEMENTED BY APPROPRIATE WRITTEN ...

THE ASSOCIATED CORPORATION PROPOSES TO INVESTIGATE AN INTERRELATED THREE-PART KNOWLEDGE BASED SYSTEM HAVING A NATURAL LANGUAGE INTERPRETER, AN EXPERT SYSTEM ANALYZER AND A NATURAL LANGUAGE GENERATOR. TECHNIQUES USING A LEXICALLY/SEMANTICALLY/FUNCTIONALLY FOCUSED DICTIONARY, PARSER, ANALYSER WHICH TAKES ADVANTAGE OF REPETITIVE LEXICAL STRINGS ARE PROPOSED FOR NATURAL LANGUAGE PROCESSING. INVESTIGAT ...

THE PROPOSED DATABASE-PHYTOMED-WILL GIVE PHARMACEUTICAL, MEDICAL, AND HERBAL-PRODUCTS RESEARCHERS A COMPREHENSIVE SOURCE OF INFORMATION ON THE USE OF PLANTS IN TRADITIONAL MEDICINE, IN PARTICULAR IN TRADITIONAL CHINESE HERBAL MEDICINE, AND WILL HELP TRANSFER EXISTING KNOWLEDGE TO MODERN MEDICINE. IT WILL ALSO HELP TRADITIONAL-MEDICINE PRACTITIONERS SELECT APPROPRIATE NATURAL-PRODUCT DRUGS. THIS DA ...

THE OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT OF A SIMPLE ANALYTICAL SYSTEM FOR THE ACCURATE ESTIMATION OF BLOOD ALCOHOL CONCENTRATION USING SALIVA AS THE SAMPLE. THESYSTEM WILL BE COMPRISED OF THE FOLLOWING: (1) A STRIP OF FILTER PAPER DESIGNED TO COLLECT AN ACCURATE VOLUME OF SALIVA; (2) A DISPOSABLE REACTION VESSEL CONTAINING STABILI-ZED ALCOHOL DEHYDROGENASE AND OTHER REAGENTS, WHICH PROVI ...

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QUANTITATIVE INDICATORS OF COMPANY TECHNOLOGICAL STRENGTH WOULD BE OF ENORMOUS VALUE TO THE CORPORATE AND FINANCIAL COMMUNITIES FOR COMPETITOR ASSESSMENTS, FOR MERGER/ACQUISITION ANALYSIS, AND IN THE GENERAL AREA OF CORPORATE TECHNOLOGICAL PLANNING AND MANAGEMENT. TODAY SUCH INDICATORS ARE ALMOST NONEXISTENT. THE PHARMACEUTICAL INDUSTRY PROVIDES A UNIQUE ARENA FOR EVALUATING VARIOUS ASPECTS OF COR ...

THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP TECHNIQUES FOR USING MONOCLONAL ANTIBODIES LABELED WITH 212BISMUTH, AN ALPHA PARTICLE-EMITTING RADIONUCLIDE, AS IN VITRO OT IN VIVOCYTOTOXIC AGENTS. ANTIBODY CONJUGATES WILL BE DEVELOPED FORRADIOIMAGING TO LOCALIZE TO THE TUMOR SITE ONLY, WITH MINIMAL UPTAKE BY THE RETICULOENDOTHELIAL SYSTEM, MAKING THEM IDEAL AGENTS FOR IMMUNOTHERAPY. THIS SITE-SPECIFIC ...

THIS PROJECT WILL DEVELOP A SYSTEM FOR THE REMOVAL OF T LYMPHOCYTES OR TUMOR CELLS FROM BONE MARROW USING IMMOBILIZED MONOCLONAL ANTIBODIES. THE SELECTIVE REMOVAL OFT CELLS FROM BONE MARROW USING IMMOBILIZED MONOCLONAL ANTIBODIES WILL PROVIDE AN EFFECTIVE SYSTEM FOR ALLOGENIC TRANSPLANT OF BONE MARROW IN A VARIETY OF DISEASE STATES. THIS SYSTEM WILL ALSO SERVE AS A MODEL FOR TUMOR REMOVAL IN AUTOL ...