Award Data

To defeat OP nerve agents, we must match both their potency and access to the synaptic cleft. Unfortunately, the most potent organophosphate antidotes cannot access neurons from the systemic circulation. Phosphotriesterase (PTE) enzyme mutants are too large, and small, cationic oximes are too charged to cross the blood-brain-barrier or blood-nerve-barrier in appreciable quantities. State-of-the-ar ...

The overall goal of this proposed project (through Phase III) is to develop the Tacrolimus At-home Saliva Test (TAST) to measure tacrolimus at ng/mL levels in oral fluid (saliva) at-home in 15-20 minutes.  The TAST will replace the painful blood tests currently performed at hospital and clinics that military patients, who have limb, facial and organ transplants, must undergo to avoid transplant r ...

Low level meteorological data over the world’s oceans is hard to collect, due to the cost and difficulty of sensor emplacement. Crewed aircraft are deployed when major weather events arise, but between those major weather events, in-situ data sources are very limited. Uncrewed aircraft systems (UAS) present a unique opportunity to inexpensively collect meteorological data from remote areas, but ...

Prescribed burns are a critical aspect of land management, but they require vegetation data that is hard to obtain at high resolution and on the timescale required. Our autonomous UAV collects critical fire modeling variables through subcanopy flight, enabling rapid surveys for faster and safer burn planning. In Phase I, we proved the feasibility of mapping live fuel moisture content (LFMC) with s ...

The purpose of the continuation of this Direct-to-Phase II effort is to develop a field-expedient, antimicrobial, hydration-providing wound dressing for acute care of large burn wounds.

In response to DHA202-002, SunFire Biotechnologies (SFB) proposed to develop a 2-fold multiplexed serum bactericidal assay (mSBA) for Shigella antibodies and to demonstrate its operational feasibility.  With that Phase I funding, SFB developed a 4-fold mSBA, based on antibiotic resistance, which allows the simultaneous testing of functional antibodies against S. flexneri serotypes 2a, 3a, and 6, ...

The Transportable Blood Storage (TBS) system is designed to transport fresh whole blood and vaccines farther and more reliably than currently available. A prototype will demonstrate the feasibility of a stackable, portable, active refrigeration unit capable of holding up to 40 units of blood without the need for any additional appliances or ice packs. Concept evaluations will be completed with 720 ...

RF weapons are an emerging battlefield threat. These directed energy weapons are being demonstrated at higher power levels and in smaller, less costly, and more mobile platforms. However, while the defense industry is just now beginning to understand the effects of high-levels of RF energy on electronic systems, through rigorous test and evaluation of instrumented targets and systems, there is sig ...

More than half of military service members sustain a musculoskeletal injury each year, and the majority of those are attributed to the lower limb, leading to millions of days of limited duty annually and reduced overall readiness.  To establish a leadership role, a solution will help strengthen holistic continuity of care across the phases of lower limb rehabilitation and enhance prevention, whil ...

Virtual human avatars will play a critical role in the next generation of advanced training environments, performance-related physiological modeling, and simulation-based design of protective armor. The overall goal of this project is to design and develop computer software for generating dynamic, mission-relevant avatar movements utilizing USARIEM’s static finite element avatars. During the ini ...