Award Data

Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

Modern DoD applications are benefiting from the proliferation of EO/IR sensor technology. As imagers become cheaper and smaller, they are being more widely deployed for a variety of scenarios. This trend is exemplified by the Navys Future Targeting System (FTS), which will provide laser designation, laser spot imaging, and some target location functions in a single 5.5-pound unit, replacing discre ...

SWIR polarimetry has potential applications for target detection, discrimination, and tracking for land and maritime environments. In recent years, researchers have applied imaging polarimetry to applications including detection of disturbed earth, detection of objects and swimmers in water, and target detection with background clutter. The application space for imaging polarimetry is increasing t ...

The output of the traditional optics fibers produce a Gaussian-shaped output due to the internal mode structure. Moreover, the output from traditional optical fibers contains spatial non-uniformities that are undesirable for certain applications. Many advanced applications require a “flat-top” intensity distribution of the laser beam as it produces uniform illumination and minimizes speckle. T ...

Tools that provide dynamic interactive 4-D (3D+time) visualization, analysis, integration, and synchronization of Joint operations for the Joint Mission Planning System (JMPS) currently do not exist or have limited capabilities. Specifically, tools are needed to generate and support 4-D geographically-referenced interactive overlays of multiple data sources for Situational Awareness (SA) to suppor ...

The assets of the US Navy are under constant threat of attack from small fast moving boats, such as the Fast Attack Craft (FAC) and the Fast Inshore Attack Craft (FIAC). These craft may be operated by forces from recognized adversaries such as Iran or North Korea, by “Rogue States” or by violent non-state actors whose ideology encourages violence against US interests. To counter this threat, t ...

Detection, classification/recognition, and tracking surface vessels on water is very challenging for many reasons. Haze, marine layer, and/or other particulates can attenuate signal and create path background radiance, all of which reduce the contrast of the target against the background. The intensity and spatial frequencies of the background often mimic the surface vessel making acquisition and ...

To address the Navy need for enhanced ambient-noise modeling for sonar-sensor performance estimation, sonar tactical decision aids (TDAs), and simulation-based training, ARiA will develop, demonstrate, and transition key building blocks for an enhanced multidimensional ambient-noise model (MDANM) needed to overcome the limitations of the current state of practice for noise modeling in sonar TDAs a ...

The Navy requires a life raft that is small enough to fit within a front pocket on the body-worn survival ensemble. Having a pocket-sized raft at hand helps facilitate successful egress, inflation, and boarding. The required 12 cubic inches of stowed volume is a significant challenge, considering that a typical one-person raft compacts to about 700 cubic inches under vacuum. Safe, Inc. (Safe) has ...