Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Dityrosine Locked Prefusion F Protein: A Path To A Protective RSV Vaccine

    SBC: AVATAR MEDICAL, LLC            Topic: NIAID

    DESCRIPTION provided by applicant The pre fusion conformation of the RSV F protein preF is the primary determinant of neutralization in immunized sera However this conformation is unstable and rapidly transitions to the postfusion conformation A disulfide stabilized prefusion variant with cavity filling mutations DS Cav has been shown to yield high neutralizing titers in animals howeve ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Ultra-low dose Influenza vaccines

    SBC: Codagenix Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Current seasonal Influenza vaccines are proving to be ineffective especially in at risk populations For example this yearandapos s inactivated flu vaccine had only a efficacy rate against H N infections in the elderly and the current live attenuated Influenza vaccine LAIV is aged restricted for those above years of age Therefore there is glaring un ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Recombinant Protein for Mitigating Total Body Radiation Injury

    SBC: THERASOURCE, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This SBIR Phase I proposal is intended to demonstrate the feasibility of developing a novel and effective therapeutic agent for acute radiation injury The threat of nuclear terrorism remains high and there is a possibility of a nuclear power plant leak both of which can cause acute radiation injury at a large scale Currently there are no therapeutic agents ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Enhancing engraftment of cord blood for treatment of neoplastic disorders

    SBC: Marrowsource Therapeutics International LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Hematopoietic stem cell transplantation is a form of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood related diseases However there currently are several drawbacks in the use of bone marrow hematopoietic cell transplantation Most importantly the donor pool is limited by the need for at least partial HLA matching and t ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Powered Walk/Run Prosthetic Ankle

    SBC: Springactive, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant In the first phase of this project it was shown that by utilizing innovative technologies it was possible to allow below the knee amputees to walk and run using a single powered prosthetic device In the second phase of this project it will be shown that the key technological advancements and optimizations will allow the a single powered device to perform wa ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Single-chain antibody countermeasures for the Radiation GI Syndrome

    SBC: CERAMIDE THERAPEUTICS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Genetic or pharmacologic inhibition of ceramide mediated cell death within the vascular endothelium of the gastrointestinal tract GI protects mice from death from the Radiation GI Syndrome RGS Prophylactic administration of anti ceramide antibody attenuates endothelial apoptosis resulting in significant protection of intestinal stem cells and animal survi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Cell therapy for Repairing Warm Ischemically Damaged Kidneys

    SBC: BREONICS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The goal of this project is address a large unmet medical need by providing more kidneys for transplant For the andgt patients with end stage renal disease in the U S the pool of cadaveric kidneys has remained stagnant over the past decade As a result the dialysis population is expected to reach andgt million patients in the next decade at an aggr ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Interactive Technology for Pediatric HIV/AIDS Treatment Adherence

    SBC: MEDIA REZ LLC            Topic: 105

    DESCRIPTION provided by applicant This study will aim to assess the feasibility and acceptability of using state of the art video game technology to increase adherence among HIV adolescents and young adults AYA ages Treatment fatigue and the desire for increasing independence among this particular population can lead to non adherence which can result in treatment resistant HIV a cri ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Preclinical Testing of Human Ghrelin for the Treatment of Stroke

    SBC: THERASOURCE, LLC            Topic: 105

    DESCRIPTION provided by applicant The ultimate objective of this program is to develop a novel therapeutic approach that will save lives of patients with stroke Acute stroke is the third leading cause of death in the United States and the primary medical cause of acquired adult disability Each year Americans experience new or recurrent stroke It accounts for out of every death ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Lab-To-Marketplace: Commercialization of a stretchable microelectrode array

    SBC: BMSEED LLC            Topic: 101

    DESCRIPTION provided by applicant The proposed work is directed at the commercialization of a stretchable microelectrode array BMSEEDandapos s sMEA a new tool that provides enhanced capabilities to simultaneously interface mechanically and electrically with cell cultures in vitro The mechanical stretching of neurons in the brain or spinal cord is often te root cause of traumatic brain injur ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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