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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 1 - 10 of 3410 results
  1. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Development and Evaluation of a Simulated Prototype to Dynamically Adjust Ambient Environments to Promote Affective Regulation in Individuals with Autism Spectrum Disorder

    SBC: SpaceFactory, Inc.            Topic: na

    The goal of the Phase I proof-of-concept project is to determine if affective and physiological regulation in individuals with autism spectrum disorders (ASD) can be promoted through dynamic adjustments in the environment. This goal will be addressed through the execution of two objectives: (1) development of an Internet of Things (IoT) prototype digital interface; and (2) evaluation of environmen ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Development of Novel Broad Spectrum Antimicrobial Corneal Tissue Storage Solutions

    SBC: IFYBER, LLC            Topic: ODCDC

    Endophthalmitis is a severe condition caused by inflammation of the ocular cavity and is a significant complication of corneal transplant proceduresoften being caused by microbial contamination of the donor tissueThe introduction of antibiotics into corneal tissue storage solutions in thes drastically lowered the incidence of bacterial endophthalmitis has drastically decreasedhoweverfungal endopht ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 380- QIDS: Using Radiomics to Impact Radiotherapy Treatment Planning- Moonshot

    SBC: HealthMyne, Inc.            Topic: NCI

    HealthMyne proposes developing a Clinical Decision Support tool to be used in the point-of-care workflow for the Radiation Oncologist that uses radiomic features that have evidence-based association to disease course and/or normal organ damage, in order to impact the treatment planning process. Phase 1 will focus on extraction, calculation, and validation of identified radiomic features for lung c ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. STEM and Health: Science Kits Integrating STEM Concepts with Human Health

    SBC: Science Take-Out, LLC            Topic: 500

    ABSTRACT Solving human health problems often involves technologies developed through the collaborative work of scientistsengineersand mathematiciansDespite the fact that STEMsciencetechnologyengineeringand mathematicscollaboration is a crucial aspect of medical research and healthcare careersmany students are still learning scienceengineeringand math as isolated disciplinesIn additionmany teachers ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Development of KLS-13019 for Chemotherapy Induced Peripheral Neuropathy and Drug Dependence

    SBC: Kannalife Sciences Inc            Topic: NIDA

    Chemotherapy induced peripheral neuropathyCIPNcan be a chronicseverely debilitating consequence of cancer therapy for which there are no effective management strategiesMoreoverupwards ofof CIPN patients reported using prescription opioids for pain management despite the fact that there is only weak evidence that long term continuation of opioids provides clinically significant pain relief in these ...

    STTR Phase I 2018 Department of Health and Human Services
  9. A Tailored Approach to Promoting Engagement in Public Health

    SBC: Transcendent International, LLC            Topic: NINR

    PROJECT SUMMARY Successfully reaching and enrolling fully representative target populations in public health interventions is a highly desiredbut notoriously difficultprospectespecially when an initiative is focused on socially charged issues or health conditions that affect vulnerable subgroupsFor exampleHIV AIDS has disproportionately high morbidity among a number of minority marginalized popula ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A Universal Flu Vaccine Based On Conformationally Locked Soluble Headless HA

    SBC: AVATAR MEDICAL, LLC            Topic: NIA

    An Influenza pandemic remains an acute threat to world healthand stockpiling a universally protective Influenza vaccine provides a strong defense against this potential catastropheThe hemagglutininHAprotein is the primary target of humoral Ab responses to Influenzathe majority of broadly protective mAbsbnAbsagainst influenza isolated from humans recognize conserved and conformation specific epitop ...

    SBIR Phase II 2018 Department of Health and Human Services

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