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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Developing Silicon Nanowire Sensors to Measuring Host-Cell Proteins at a Biomanufacturing Line

    SBC: Advanced Silicon Group            Topic: None

    Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  2. Nanomachine Device for Semiconductor Process Control Monitoring

    SBC: Xallent LLC            Topic: None

    Conventional characterization and test methods are increasingly ineffective when applied to structures less than 100 nanometers, causing challenges across R&D, process control and failure analysis. An increasing number of subtle defects become prominent drivers of failure as device size and operating margins decrease, e.g., processing anomalies in thin gate oxides, substrate problems related to do ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Direct Performance Evaluation of Additive Manufacturing Process Plans

    SBC: INTACT SOLUTIONS INC.            Topic: None

    Additive manufacturing is steadily advancing towards fulfilling its promise of customized and on-demand production of functional parts. However, performance of as-manufactured parts can differ significantly from the as-designed parts because the as-manufactured geometry differs from the as-designed geometry and the asmanufactured material properties are not known. Attempts to predict performance o ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  4. Continuous Learning for Additive Manufacturing Processes Through Advanced Data Analytics

    SBC: Senvol LLC            Topic: NA

    Additive manufacturing (AM) is a promising manufacturing technique for end-use parts that can solve challenges for American manufacturers in many industries, e.g. aerospace, defense, automotive, energy, and healthcare. However, despite the potential that AM offers, the rate of AM adoption in industry is very slow. This is because AM suffers from low repeatability and quality consistency issues, wh ...

    SBIR Phase I 2018 Department of CommerceNational Institute of Standards and Technology
  5. Measuring the Concentration of Host-cell Proteins in Biomanufacturing Using Silicon Nanowire Array Sensors

    SBC: Advanced Silicon Group            Topic: NA

    Our innovation is a low cost, sensitive, quantitative biosensor that can detect many biomarkers on the same chip. Our sensor consists of vertically aligned silicon nanowires. The silicon nanowires’ high surface area to volume ratio makes them sensitive to the environment around them and can thus lead to high sensitivity detection. Each of the nanowires can be functionalized to be sensitive to ei ...

    SBIR Phase I 2018 Department of CommerceNational Institute of Standards and Technology
  6. High-Throughput Single-Nanoparticle Magnetic Analysis Platform Using Diamond Magnetic Imaging

    SBC: Quantum Diamond Technologies Inc            Topic: NA

    Magnetic nanoparticles are widely-used tools over a range of industries, but have particularly powerful biomedical applications for clinical and research diagnostics, clinical therapy, and basic life science research. Many of these applications require consistent sources for magnetic nanoparticles with narrow distributions of magnetic properties, but no technology is now commercially available for ...

    SBIR Phase II 2017 Department of CommerceNational Institute of Standards and Technology
  7. High Temperature High Resolution in-situ Differential Pressure Sensor

    SBC: Innoveering, LLC            Topic: NA

    Chemical manufacturers require high accuracy/high sensitivity pressure sensors to efficiently monitor the various manufacturing systems and processes in the chemical plant, to ensure any changes proceed in a safe and reliable manner, adhering to expected standards and practices. NIST also has a need for highly accurate pressure measurements, especially determining the thermo-physical properties of ...

    SBIR Phase II 2017 Department of CommerceNational Institute of Standards and Technology
  8. High-Throughput Single-Nanoparticle Magnetic Analysis Platform Using Diamond Magnetic Imaging

    SBC: Quantum Diamond Technologies Inc            Topic: 90109

    Magnetic nanoparticles are powerful tools over a wide range of industries, but have particularly powerful biomedical applications for clinical and research diagnostics, clinical therapy, and basic life science research. These applications require consistent sources for magnetic nanoparticles with narrow distributions of magnetic properties, but no technology is now commercially available for manuf ...

    SBIR Phase I 2016 Department of CommerceNational Institute of Standards and Technology
  9. High Temperature High Resolution in-situ Differential Pressure Sensor

    SBC: Innoveering, LLC            Topic: 90105

    Chemical manufacturers require high accuracy and high sensitivity pressure sensors to efficiently monitor the various manufacturing systems and processes in the chemical plant, to ensure any changes proceed in a safe and reliable manner, adhering to expected standards and practices. In addition, NIST has a need for highly accurate absolute and differential pressure measurements, especially for det ...

    SBIR Phase I 2016 Department of CommerceNational Institute of Standards and Technology
  10. A Category-theoretic Tool for Manufacturing Information Integration

    SBC: CATEGORICAL INFORMATICS, INC.            Topic: 90101

    Category theory has recently been successfully applied to translate information from one computer system to another. Researchers at MIT have developed a prototype software tool based on category theory for solving information-integration programs. The tool has successfully solved small-scale information-integration problems including a problem identified by NIST about enriching the manufacturing s ...

    SBIR Phase II 2016 Department of CommerceNational Institute of Standards and Technology

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