Award Data

Bacteriophages (phages) are becoming important therapeutic candidates against multidrug resistant (MDR) bacterial infections. There is a need to isolate and concentrate phages collected from the field to enhance specimen storage stability for long-distance transport to specialized laboratories for subsequent analysis. Environmental phage preparation requires expensive, bulky instrumentation and in ...

Prescribed burns are a critical aspect of land management, but they require vegetation data that is hard to obtain at high resolution and on the timescale required. Our autonomous UAV collects critical fire modeling variables through subcanopy flight, enabling rapid surveys for faster and safer burn planning. In Phase I, we proved the feasibility of mapping live fuel moisture content (LFMC) with s ...

To defeat OP nerve agents, we must match both their potency and access to the synaptic cleft. Unfortunately, the most potent organophosphate antidotes cannot access neurons from the systemic circulation. Phosphotriesterase (PTE) enzyme mutants are too large, and small, cationic oximes are too charged to cross the blood-brain-barrier or blood-nerve-barrier in appreciable quantities. State-of-the-ar ...

This PHASE II two-year proposal is designed to expand upon the knowledge gained already in the PHASE I research regarding the development of rapid bioresorbable glasses to bring us to the making of prototype stents which would be ready for testing in animals and humans. Motivated by the success of PHASE I research, wherein several bioresorbable glasses in the Na2O-K2O-CaO-B2O3-P2O5 have been devel ...

Multidrug resistant (MDR) bacterial wound infections remain a persistent challenge for front-line military medical providers in prolonged care treatment. Bacteriophage (phage) therapeutics have demonstrated preclinical and clinical efficacy against ESKAPEE infections. Phage production however remains a challenge to remove common pyrogen contaminants from phage products, including endotoxins (lipop ...

RF weapons are an emerging battlefield threat. These directed energy weapons are being demonstrated at higher power levels and in smaller, less costly, and more mobile platforms. However, while the defense industry is just now beginning to understand the effects of high-levels of RF energy on electronic systems, through rigorous test and evaluation of instrumented targets and systems, there is sig ...

The purpose of the continuation of this Direct-to-Phase II effort is to develop a field-expedient, antimicrobial, hydration-providing wound dressing for acute care of large burn wounds.

The ability to quickly test materials during new technology development would provide actionable insight that would significantly reduce materials and device design iterations and accelerate time-to-market. However, conventional characterization and test methods are increasingly ineffective when applied to structures less than 100 nanometers, causing challenges across R&D, process control, and fai ...

Virtual human avatars will play a critical role in the next generation of advanced training environments, performance-related physiological modeling, and simulation-based design of protective armor. The overall goal of this project is to design and develop computer software for generating dynamic, mission-relevant avatar movements utilizing USARIEM’s static finite element avatars. During the ini ...

In response to DHA202-002, SunFire Biotechnologies (SFB) proposed to develop a 2-fold multiplexed serum bactericidal assay (mSBA) for Shigella antibodies and to demonstrate its operational feasibility.  With that Phase I funding, SFB developed a 4-fold mSBA, based on antibiotic resistance, which allows the simultaneous testing of functional antibodies against S. flexneri serotypes 2a, 3a, and 6, ...