Award Data

This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a system that, while being inexpensive and simple to use, will be able to generate variable domains of heavy chain-only llama antibodies (also called VHHs, or nanobodies) targeted to antigens of interest in vitro. This system will not require llama vaccinations and will use universal pre-fabricated libraries fo ...

This Small Business Innovation Research (SBIR) Phase I project has a goal of creating a system that, while being inexpensive and simple to use, will be able to analyze samples for the presence of a live pathogenic bacteria and determine their species, as well as sensitivities to antibiotics within just a few hours. As detectors, this system will utilize modified bacteriophages. To prove the concep ...

Current research tools to understand tumor cell migration and metastases are limited to linear gradients or constant flow across cells skewing results. Researchers at the National Institute of Standards and Technology developed a tool called the microfluidic palette which exposes cells to chemical stimuli in a static environment overcoming the limitations above. Several improvements are necessary ...

This Small Business Innovation Research Phase II project will develop an enhanced pulse oximeter prototype ready for external demonstration. The key innovation of the prototype will be the Intelligent Data Extraction Algorithm (IDEA), which during Phase I demonstrated extraction of embedded hemodynamic information from photoplethysmograms, including left-ventricular stroke volume and cardiac outpu ...

This SBIR Phase I project will develop software for comprehensive evaluation of algal production systems. Standard models from literature for fluid flow (mass, turbulence, momentum), energy, light distribution, photosynthesis, algae growth and concentration, gas transfer, and heat transfer will be incorporated into the software. The innovative component of this proposal is the integration of exi ...

This Small Business Innovation Research (SBIR) Phase I project aims to develop a novel textile coating and reading device for positive identification applications such as anti-counterfeit, textile brand verification, etc. The basis of this project is to use a layer-by-layer self-assembly process to control the interface between engineered textile substrates and nanomaterials. The resulting nanost ...

This Small Business Innovation Research (SBIR) Phase I project aims to develop an ultrahigh speed, precision, micro-milling spindle. The trends in industrial and military products that demand miniaturization, design flexibility, reduced energy consumption and high accuracy continue to accelerate -- especially in the medical, biotechnology, telecommunications and energy fields. These industry segme ...

This Small Business Innovation Research (SBIR) Phase I project aims to investigate the feasibility of an innovative, super-homodyne interferometer for high-precision distance measurement with long dynamic range (more than two orders larger than the fundamental wavelength) and high resolution (less than one half-wavelength). If successful, this would represent the longest working distance of any r ...

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel biomimetic adhesive for seroma prevention. Commercial bioadhesives have demonstrated mixed results as they are hampered by weak adhesive strengths, the need to mix precursors, and undesirable degradation rates. Thus, there continues to be an unmet clinical need for the development of a new and improved adhes ...

This Small Business Innovation Research Phase I project aims to design and develop an automated, behavior-based, malware analytics software system. This system addresses the growing problem of significant delay between a malware outbreak and the response from the IT security community. The response time to malware outbreaks is becoming increasingly longer - sometimes as long as 2 months or longer ...