Award Data

Measurement of vital signs (VS) is essential to assess the condition of human body. VS includes body temperature (Tc), heart (pulse) rate (HR), respiration rate (RR) and blood pressure (BP). VS are useful in detecting medical problems. Typically VS measurement and monitoring takes place in a controlled setting like hospital, clinic or home using bulky contact based machines. In order to monitor VS ...

Accurate core temperature measurement is critical for safe assessment of warfighter operational readiness since it is a parameter strongly associated with environmental temperature-related injuries and exertional heat exhaustion of thermally burdened soldiers. Yet, this variable is still incredibly challenging to measure accurately, reliably, noninvasively, and cost-effectively. Because of this, i ...

To defeat OP nerve agents, we must match both their potency and access to the synaptic cleft. Unfortunately, the most potent organophosphate antidotes cannot access neurons from the systemic circulation. Phosphotriesterase (PTE) enzyme mutants are too large, and small, cationic oximes are too charged to cross the blood-brain-barrier or blood-nerve-barrier in appreciable quantities. State-of-the-ar ...

RF weapons are an emerging battlefield threat. These directed energy weapons are being demonstrated at higher power levels and in smaller, less costly, and more mobile platforms. However, while the defense industry is just now beginning to understand the effects of high-levels of RF energy on electronic systems, through rigorous test and evaluation of instrumented targets and systems, there is sig ...

The purpose of the continuation of this Direct-to-Phase II effort is to develop a field-expedient, antimicrobial, hydration-providing wound dressing for acute care of large burn wounds.

There is a great need for disruptive technology to enhance the success rate of endotracheal intubation (ETI) procedures.  Complications frequently occur not only with difficult airway patients, but with patients with trauma and those with no apparent anatomical challenges.  Complications occur with military casualties, both prior to and after arrival at Combat Support Hospitals, and in austere a ...

As military operations expand into multi-domains against near-peer adversaries, anti-access and area denial technologies limit the ability for the U.S. military to successfully evacuate wounded

Robotic and Autonomous Systems (RAS) are a critical component of military operations on the battlefield of the future. RAS are capable of performing complex, dangerous tasks, thereby reducing risk to Service members. Extraction of wounded individuals from dangerous areas so they can receive medical attention is an ideal application of RAS. However, there has been relatively little research and dev ...

Nanoparticles (NPs) frequently are selected to deliver therapeutic agents due to their unique properties, which improve systemic delivery. Notably, the properties of NPs are highly tunable and enable cell-specific targeting of their payload in addition to protecting the therapeutic agent from clearance. For example, recent work demonstrated that anionic NPs selectively target neurons. This charge- ...

To defeat OP nerve agents, we must match both their potency and access to the synaptic cleft. Unfortunately, the most potent organophosphate antidotes cannot access neurons from the systemic circulation. Phosphotriesterase (PTE) enzyme mutants are too large, and small, cationic oximes are too charged to cross the blood-brain-barrier or blood-nerve-barrier in appreciable quantities. State-of-the-ar ...