Award Data

The E.coREADi technology leverages a proprietary enrichment method with high specificity and sensitivity fluorescent enzyme activity assays to detect target organisms. Originally developed as an assay kit to facilitate E. coli testing within wastewater effluents aboard US Navy vessels and ensure EPA compliance prior to discharging treated water, the E.coREADi technology is currently being refined ...

The direct and indirect effects of severe and prolonged tissue hypoxia due to hemorrhagic shock are leading causes of death following battlefield injuries. About 20% of all battlefield deaths are potentially survivable. Of these, most service members (84%) suffered hemorrhage and potentially could have been saved.  Resuscitation in the field is often seriously inadequate even in patients transpor ...

Measurement of vital signs (VS) is essential to assess the condition of human body. VS includes body temperature (Tc), heart (pulse) rate (HR), respiration rate (RR) and blood pressure (BP). VS are useful in detecting medical problems. Typically VS measurement and monitoring takes place in a controlled setting like hospital, clinic or home using bulky contact based machines. In order to monitor VS ...

Bacteriophages (phages) are becoming important therapeutic candidates against multidrug resistant (MDR) bacterial infections. There is a need to isolate and concentrate phages collected from the field to enhance specimen storage stability for long-distance transport to specialized laboratories for subsequent analysis. Environmental phage preparation requires expensive, bulky instrumentation and in ...

Accurate core temperature measurement is critical for safe assessment of warfighter operational readiness since it is a parameter strongly associated with environmental temperature-related injuries and exertional heat exhaustion of thermally burdened soldiers. Yet, this variable is still incredibly challenging to measure accurately, reliably, noninvasively, and cost-effectively. Because of this, i ...

The rate of ankle sprains in military personnel is nearly five times greater than that reported in the civilian population. To minimize the impact of these injuries on Warfighter readiness and lethality, effective preventative and rehabilitative methods are required. However, to prescribe accurate rehabilitative methods clinicians must be able to measure ankle instability (a hallmark of ankle spra ...

Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by poor pulmonary gas exchange, typically caused by some form of lung injury. Current treatment options are limited, often relying on oxygen treatments and mechanical ventilation, with severe cases requiring extracorporeal membrane oxygenation (ECMO) for supportive care. These treatment options can lead to sig ...

To defeat OP nerve agents, we must match both their potency and access to the synaptic cleft. Unfortunately, the most potent organophosphate antidotes cannot access neurons from the systemic circulation. Phosphotriesterase (PTE) enzyme mutants are too large, and small, cationic oximes are too charged to cross the blood-brain-barrier or blood-nerve-barrier in appreciable quantities. State-of-the-ar ...

This PHASE II two-year proposal is designed to expand upon the knowledge gained already in the PHASE I research regarding the development of rapid bioresorbable glasses to bring us to the making of prototype stents which would be ready for testing in animals and humans. Motivated by the success of PHASE I research, wherein several bioresorbable glasses in the Na2O-K2O-CaO-B2O3-P2O5 have been devel ...

Advancements in combat aircraft performance and flight equipment design, particularly the use of helmet-mounted display systems (HMDS), have led to an increase in reported neck pain and injury due to G loading among aircrew. These helmet-supported masses shift the center of gravity (CG) forward and superior to the normal CG. With this shifted CG, both low G loading during prolonged use and high G ...