Award Data

The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase I project promotes and enhances transparency in the democratic process. It accomplishes this by developing a social awareness system that can detect, understand, and predict opinion trends within a democratic society. Through the development of cutting-edge artificial intelligence (AI) techniques, the project con ...

The broader impact of this Small Business Innovation Research (SBIR) Phase II project is improving the surgical outcome for patients undergoing neuro-endovascular interventions for the treatment of intracranial aneurysms (IAs). IAs affect 6% of the population and IA rupture results in lethal hemorrhagic strokes, which account for ~25% of cerebrovascular deaths despite improvements in management. M ...

The goal for this Phase I research is to develop a stretchable dielectric ink that can be used for flexible applications. Printing electronics is a new and quickly growing alternative to traditionally manufactured electronics. Flexible hybrid electronics (FHE) is a novel approach to electronic circuit manufacturing that aims to combine the best of printed and conventional electronics. FHE devices ...

Commercial buildings use 35% of the entire US energy output, and up to a third of that energy is wasted. Rapidly rising fuel costs, increasing concern about climate change, and policy directives from the Biden Administration are all driving the need for increased energy efficiency and the elimination of waste. At the same time, the COVID-19 pandemic has dramatically increased public awareness of t ...

This Small Business Technology Transfer (STTR) Phase II project contributes to broader societal and commercial impacts by enabling crime labs to better utilize overstretched resources by ensuring only relevant crime scene samples undergo DNA analysis. Currently, the large number of irrelevant samples submitted for testing contributes to a massive backlog that clogs up crime lab workflows and delay ...

Project SummaryImpairment in instrumental activities of daily living (IADL) is a hallmark of Alzheimer’s disease (AD) dementia and a major source of patient and caregiver burden. Similarly to cognitive changes in AD, subtle difficulties in IADL may begin even before the stage of amnestic mild cognitive impairment (MCI). Recently, greater emphasis has been placed on preclinical AD, which consists ...

Abstract DUB Biologics is developing a therapeutic for the prevention and treatment of corneal scarring through knockdown of a novel target that has been shown to be central to the fibrotic response leading to corneal opacification. Corneal opacification severely impairs the vision of 4.2 million people around the world, 5.1% of the total blind population. Monocular scarring is far more common, af ...

PROJECT SUMMARY Opioid and/or Stimulant Use Disorders (OUD/StUD) are chronic, recurring conditions that if left untreated, pose a significant and ongoing public health and safety threat, with costs associated with OUD alone in the US exceeding one trillion dollars annually. Virtual Reality Cue Exposure (VRCE) employs safe and controlled repeated exposure to a variety of substance use cues and envi ...

PROJECT SUMMARY Early treatment with effective antibiotics significantly improves clinical outcomes associated with bloodstream infection. However, the phenotypic antimicrobial susceptibility tests (AST) required to choose the right antibiotics take 4-24 hours (often longer in practice) following a 24–48-hour culture, which significantly exceeds the window within which treatment must begin to av ...

Project AbstractOur overarching goal is to provide reliable and efficient tools that can be used in structure based drug discovery (SBDD). One crucial component of SBDD is to predict the structure of a drug molecule that binds to a protein involved in a certain disease. This is usually achieved using computer tools and the process consists of two steps, namely hit identification and lead optimizat ...