Award Data

DESCRIPTION provided by applicant The goal of this project is to develop a commercial software package for rapid Monte Carlo based dose computation in imaging and radiation therapy The product takes advantage of a desktop parallel computer equipped with emerging hardware originally developed gaming and high performance computing The project is motivated by the fact that the market is ripe for ...

By the time an individual is diagnosed with Alzheimer s Disease AD or dementia they have often already experienced both gradual and dramatic changes to their health cognitive function employment and financial status among other life events A number of key interview based studies like The National Health and Aging Trends Study NHATS and The Health and Retirement Study HRS have provided u ...

DESCRIPTIONprovided by applicantThe goal of this project is to develop a commercial software package for rapid Monte Carlo based dose computation in imaging and radiation therapyThe product takes advantage of a desktop parallel computer equipped with emerging hardware originally developed gaming and high performance computingThe project is motivated by the fact that the market is ripe for a produc ...

DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

PROJECT SUMMARY ABSTRACTThis program aims to develop a novel storage method for human ovarian tissue and whole ovarieswhich can also be applied to testicular tissue and gonadal preservation as well as a variety of cellstissuesand whole organsThis multi pronged approach builds on recent advances in machine perfusionnature inspired cytoprotection strategiesand non toxic cryoprotectant solutionscombi ...

This project aims to develop a human derived Hemoglobin Based Oxygen Carrier HBOC solution Phase I to be utilized in numerous ex vivo applications Phase II where an oxygen delivery solution is required machine perfusion MP systems for organ and tissue preservation MP systems for the discovery of biomarkers and perfusate in human microchips for drug discovery This is the first ...

Project Summary The broad goal of this project is the pharmacological validation of GIV a nonreceptor guanine nucleotide exchange factor GEF for liver fibrosis GIV sits at the hub of profibrogenic signaling in liver fibrosis and is required for the key physiological events that lead to this condition the migration proliferation and extracellular matrix deposition of hepatic stellate cells ...

Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

DESCRIPTION provided by applicant st Playable Productions and Union College propose to develop a commercializable product combining physical exercise and cognitive activities through interactive gaming on a stationary bicycle to help prevent cognitive decline and dementia in older adults The Interactive Physical and Cognitive Exercise System iPACES developed by Union Collegeandapos s Health ...

DESCRIPTION provided by applicant Male hypogonadism results from failure of the testes to produce sufficient sex hormones Aging is the greatest cause of primary hypogonadism otherwise known as testosterone deficiency syndrome TDS and in the United States affects million men while undiagnosed cases of TDS are upwards of million men TDS adversely affects male health and has been lin ...