Award Data

DESCRIPTION (provided by applicant): The goal of this research is develop therapeutic products for Cryptosporidium parvum which can be made at a scale and cost which are feasible for delivery to large populations of patients or individuals at risk, as may be necessary in countering bioterrorism, or in protecting field-deployed armed forces. Our approach is to develop recombinant neutralizing mon ...

DESCRIPTION provided by applicant Pulmokine is developing a novel inhaled PDGF receptor PDGFR kinase inhibitor PK as a treatment for Pulmonary Arterial Hypertension PAH The purpose of this Phase IIB Small Market Bridge Award is to progress PK through a phase A clinical trial for safety PAH is an orphan disease with high morbidity and mortality despite currently available treat ...

DESCRIPTION provided by applicant Pharmaco Photonics DBA FAST Biomedical proposes a PHASE IIB project to determine the safety and functionality of repeat administration of the FAST PV and mGFR Technology in both non clinical and clinical studies The long term goal of this SBIR project is to test FASTandapos s fluorescent based test in humans and commercializes this product for rapid detecti ...

DESCRIPTION provided by applicant Autism spectrum disorder ASD is now diagnosed in of children with recent reports citing as many as in children in the United States The average age of diagnosis is more than years There is a need for a reliable biomarker based test for earlier diagnosis of ASD in young children to improve outcomes such as cognition social function and communic ...

Impact Technologies, in cooperation with Standard Aero and Northrop Grumman, will lead an effort to develop a web-based software tool capable of optimizing the maintenance repair and overhaul work scopes associated with gas turbine engines that yield realistic cost estimates on a per engine flying hour basis, including post-maintenance performance metrics and expected time on wing predictions. Th ...

DESCRIPTION (provided by applicant): The goal of this application is to develop a genetically engineered therapeutic human skin substitute with enhanced antimicrobial and angiogenenic properties for use in the treatment of type 1 diabetic skin ulcers. Chronic diabetic skin ulcers exhibit poor blood flow and typically become infected resulting in impaired wound healing and amputation, a life thr ...

DESCRIPTION (provided by applicant): In this Fast Track application, we propose developing the novel imaging technology and molecular probe that will enable the non-invasive detection and quantification of HER2 overexpression in breast cancers. The approach we are promoting is to label Herceptin, a therapeutic mono-clonal antibody, with an infraredabsorbing dye, and then to detect the presence ...

DESCRIPTION provided by applicant The global HIV AIDS epidemic continues to be fueled by the large number of individuals who do not know that they are infected The CDC is supporting programs to decrease this number by encouraging more frequent testing of all age groups as well as increasing the venues for testing including the recent FDA approval of an oral HIV Screening test for anti HIV anti ...

Abstract The goal of this fast track SBIR proposal is to file an investigational new drugINDapplication for testing a novel anticancer drugFLthat is designed to overcome inherent and acquired treatment resistanceMany types of cancers are not detected until they are very advanced and have already become resistant to FDA approved treatmentsIn additionmany non advanced cancers respond well to initial ...

Future missile systems will abandon the traditional hemi-spherical shape for shapes resembling a tangent Ogive. An ogive shaped dome has better aerodynamic capabilities than its spherical counterpart. This enables the missile to fly faster, farther, and with more accuracy while also increasing its payload capacity. The optical material of choice is polycrystalline alumina, PCA, which is a hard cer ...