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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An inhaled PDGF receptor inhibitor for the treatment of pulmonary arterial hypertension

    SBC: Pulmokine, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Pulmokine is developing a novel inhaled PDGF receptor PDGFR kinase inhibitor PK as a treatment for Pulmonary Arterial Hypertension PAH The purpose of this Phase IIB Small Market Bridge Award is to progress PK through a phase A clinical trial for safety PAH is an orphan disease with high morbidity and mortality despite currently available treat ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Clinical and Non Clinical Evaluations of repeat administrations of the FAST PV and mGFR Technology

    SBC: PHARMACOPHOTONICS, INC.            Topic: 400

    DESCRIPTION provided by applicant Pharmaco Photonics DBA FAST Biomedical proposes a PHASE IIB project to determine the safety and functionality of repeat administration of the FAST PV and mGFR Technology in both non clinical and clinical studies The long term goal of this SBIR project is to test FASTandapos s fluorescent based test in humans and commercializes this product for rapid detecti ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Conformational Stabilization of the HIV-1 Env Trimer

    SBC: AVATAR MEDICAL, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Avatar is developing HIV vaccine immunogens based on dityrosine DT crosslinking of soluble native Env gp trimers Several of the most potent broadly neutralizing Abs andquot bnAbsandquot preferentially bind native Env trimers and a trimeric immunogen thus would both present a wide range of key neutralizing epitopes and simultaneously focus immune responses away fro ...

    SBIR Phase II 2013 Department of Health and Human Services
  4. A Rapid Portable HIV Detection and Monitoring System for Low Resource Settings

    SBC: THERMAL GRADIENT, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Rapid Portable HIV Detection and Monitoring System The long term objectives of this project are Develop a prototype of a rapid portable instrument for detecting and measuring the amount of Human Immunodeficiency Viruses HIVandapos s in samples of patient blood particularly in low resource settings Carry out a pilot study to establish the effectivene ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Magnetic Flow Sorter for Pancreatic Islet Isolation

    SBC: TECHSHOT, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Techshot, Inc. has successfully completed SBIR Phase I and Phase II research demonstrating that magnetically labeled porcine islets of Langerhans can be isolated from contaminating exocrine tissue by flow sorting usinga quadrupole magnetic separator ( Quadrasep ) designed for that purpose. Magnetically sorted islets are superior in morphology and physiology to ...

    SBIR Phase II 2013 Department of Health and Human Services
  6. Magnetic Flow Sorter for Pancreatic Islet Isolation

    SBC: TECHSHOT, INC.            Topic: 200

    DESCRIPTION provided by applicant Techshot Inc has successfully completed SBIR Phase I and Phase II research demonstrating that magnetically labeled porcine islets of Langerhans can be isolated from contaminating exocrine tissue by flow sorting using a quadrupole magnetic separator andquot Quadrasepandquot designed for that purpose Magnetically sorted islets are superior in morphology and ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  7. A Metabolism Based Test to Diagnose Autism Spectrum Disorder and its Subtypes in Early Childhood

    SBC: STEMINA BIOMARKER DISCOVERY, INC            Topic: 101

    DESCRIPTION provided by applicant Autism spectrum disorder ASD is now diagnosed in of children with recent reports citing as many as in children in the United States The average age of diagnosis is more than years There is a need for a reliable biomarker based test for earlier diagnosis of ASD in young children to improve outcomes such as cognition social function and communic ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. A Rapid Portable HIV Detection and Monitoring System for Low Resource Settings

    SBC: THERMAL GRADIENT, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Rapid, Portable HIV Detection and Monitoring System The long term objectives of this project are: 1. Develop a prototype of a rapid portable instrument for detecting and measuring the amount of Human Immunodeficiency Viruses (HIV's) in samples of patient blood, particularly in low resource settings. 2. Carry out a pilot study to establish the effectiveness ...

    SBIR Phase II 2013 Department of Health and Human Services
  9. Organocatalysis for the treatment of sickle cell disease

    SBC: Nanometics LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is a global health issue that affects ~100,000 Americans and over 13 million people worldwide. The complexity of the disease dictates that a multimodal approach to treatment will likely be needed. SCD is manifested physiologically during acute events of sickle crisis as the distorted red blood cells impede blood flow, causing physiolog ...

    SBIR Phase II 2013 Department of Health and Human Services
  10. Novel Prebiotic Fiber as Targeted Dietary Management of Irritable Bowel Syndrome

    SBC: NUTRABIOTIX, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): The objective of this Phase II SBIR application is to test NTX-1 fiber in patients with constipation-predominant IBS (IBS-C) and determine if it can reduce symptoms, beneficially modify gut microbiota composition, and improve gut milieu in these patients. Our hypothesis for the Phase II study is that NTX-1 fiber is better tolerated (i.e. has less side effects) ...

    SBIR Phase II 2013 Department of Health and Human Services

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