Award Data

DESCRIPTION provided by applicant Coronaviruses CoV are RNA viruses that cause gastrointestinal respiratory and neurological symptoms in several mammalian species The outbreak of the severe acute respiratory syndrome CoV SARS CoV in humans was fatal in of infected patients infecting people and killing The recent incidents involving the highly pathogenic Middle East ...

In this Phase II SBIR project, Daniel H. Wagner Associates (DHWA), with NASAs Jet Propulsion Laboratory (JPL), MARK Resources, Inc. (MRI), and Spatial Integrated Systems (SIS) as our subcontractors, will develop a prototype lightweight, low-cost Wave Detection, Prediction, and Reaction System (WDPRS), and then test and evaluate its performance at-sea. The proposed WDPRS is designed to reduce the h ...

DESCRIPTION provided by applicant Huntingtonandapos s Disease HD is an inherited disease that results from expansion of a trinucleotide CAG cytosine adenine guanine repeat that encodes a polyglutamine tract in the huntingtin protein Psychiatric symptoms including irritability and aggression are common in HD patients These are among the most distressing aspects of the disease They hav ...

DESCRIPTION provided by applicant Multi drug resistance in Enterobacteriaceae is regarded as a healthcare crisis This crisis has been further amplified by the recent emergence of the NDM andquot super bug geneandquot a zinc based metallo lactamase Amber Class B in Enterobacteriaceae Members of this family of resistance enzymes are found on promiscuous plasmids with other MDR resistance mechanisms ...

DESCRIPTION provided by applicant Multi drug resistance in Enterobacteriaceae is regarded as a healthcare crisis While carbapenems are among the most prescribed antibiotics for infections caused by these organisms carbapenem resistance conferred by zinc based metallo carbapenemases Amber Class B is a growing global health concern that threatens to erode the efficacy of these antibiotics both in th ...

DESCRIPTION provided by applicant Pulmokine is developing a novel inhaled PDGF receptor PDGFR kinase inhibitor PK as a treatment for Pulmonary Arterial Hypertension PAH The purpose of this Phase IIB Small Market Bridge Award is to progress PK through a phase A clinical trial for safety PAH is an orphan disease with high morbidity and mortality despite currently available treat ...

DESCRIPTION provided by applicant Pharmaco Photonics DBA FAST Biomedical proposes a PHASE IIB project to determine the safety and functionality of repeat administration of the FAST PV and mGFR Technology in both non clinical and clinical studies The long term goal of this SBIR project is to test FASTandapos s fluorescent based test in humans and commercializes this product for rapid detecti ...

DESCRIPTION provided by applicant Avatar is developing HIV vaccine immunogens based on dityrosine DT crosslinking of soluble native Env gp trimers Several of the most potent broadly neutralizing Abs andquot bnAbsandquot preferentially bind native Env trimers and a trimeric immunogen thus would both present a wide range of key neutralizing epitopes and simultaneously focus immune responses away fro ...

DESCRIPTION provided by applicant Rapid Portable HIV Detection and Monitoring System The long term objectives of this project are Develop a prototype of a rapid portable instrument for detecting and measuring the amount of Human Immunodeficiency Viruses HIVandapos s in samples of patient blood particularly in low resource settings Carry out a pilot study to establish the effectivene ...

DESCRIPTION (provided by applicant): Techshot, Inc. has successfully completed SBIR Phase I and Phase II research demonstrating that magnetically labeled porcine islets of Langerhans can be isolated from contaminating exocrine tissue by flow sorting usinga quadrupole magnetic separator ( Quadrasep ) designed for that purpose. Magnetically sorted islets are superior in morphology and physiology to ...