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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An inhaled PDGF receptor inhibitor for the treatment of pulmonary arterial hypertension

    SBC: Pulmokine, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Pulmokine is developing a novel inhaled PDGF receptor PDGFR kinase inhibitor PK as a treatment for Pulmonary Arterial Hypertension PAH The purpose of this Phase IIB Small Market Bridge Award is to progress PK through a phase A clinical trial for safety PAH is an orphan disease with high morbidity and mortality despite currently available treat ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. A Metabolism Based Test to Diagnose Autism Spectrum Disorder and its Subtypes in Early Childhood


    DESCRIPTION provided by applicant Autism spectrum disorder ASD is now diagnosed in of children with recent reports citing as many as in children in the United States The average age of diagnosis is more than years There is a need for a reliable biomarker based test for earlier diagnosis of ASD in young children to improve outcomes such as cognition social function and communic ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Point-of-care Detection of HIV Antibodies and RNA in Blood and Saliva

    SBC: Rheonix, Inc.            Topic: NIDCR

    DESCRIPTION provided by applicant The global HIV AIDS epidemic continues to be fueled by the large number of individuals who do not know that they are infected The CDC is supporting programs to decrease this number by encouraging more frequent testing of all age groups as well as increasing the venues for testing including the recent FDA approval of an oral HIV Screening test for anti HIV anti ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A small molecule broad spectrum inhibitor of antiapoptotic genes to treat cancer

    SBC: CANGET BIOTEKPHARMA, LLC            Topic: 102

    Abstract The goal of this fast track SBIR proposal is to file an investigational new drugINDapplication for testing a novel anticancer drugFLthat is designed to overcome inherent and acquired treatment resistanceMany types of cancers are not detected until they are very advanced and have already become resistant to FDA approved treatmentsIn additionmany non advanced cancers respond well to initial ...

    SBIR Phase II 2015 Department of Health and Human Services
  5. Aerodynamic Dome Manufacturing Cost Reduction

    SBC: OPTIPRO SYSTEMS, LLC            Topic: N132121

    Future missile systems will abandon the traditional hemi-spherical shape for shapes resembling a tangent Ogive. An ogive shaped dome has better aerodynamic capabilities than its spherical counterpart. This enables the missile to fly faster, farther, and with more accuracy while also increasing its payload capacity. The optical material of choice is polycrystalline alumina, PCA, which is a hard cer ...

    SBIR Phase II 2015 Department of DefenseNavy
  6. Clinical Translation of an Anti-Metastatic Antibody for Breast Cancer Therapy

    SBC: FOR-ROBIN, INC.            Topic: 102

    DESCRIPTION provided by applicant Translational studies are proposed to support the continued development of the JAA F antibody based therapy to address the critical need for a safe and effective treatment for metastatic breast cancer including triple negative breast cancers Building on the success of our Phase I project the overarching objectives of the Phase II application are to advanc ...

    STTR Phase II 2015 Department of Health and Human Services

    SBC: VITATEX INC            Topic: NCI

    Recent studies show that proliferative and invasion competent circulating tumor cells CTCs are invaluable in many downstream applications that depend on the ability of the isolated tumor cells to recapitulate tumor growth and metastasis in xenograft mouse models The long term objective of this proposal is to convert the existing Vitatex CTC preparation tube to a closed vacutainer system that is ...

    SBIR Phase I 2015 Department of Health and Human Services
  8. Superconducting RF Injector for High-Power Free-Electron Lasers (FEL)

    SBC: Advanced Energy Systems, Inc            Topic: N/A

    With the achievement of 1.7 kW CW IR operation and an upgrade to 10kW in progress, free-electron lasers (FEL) are now a serious option for high-power, military and commercial applications. As specifically identified in the recent

    SBIR Phase II 2001 Department of DefenseMissile Defense Agency
  9. Hydrogen Wave Heater for Nuclear Thermal Propulsion Component Testing

    SBC: ACENT LABORATORIES LLC            Topic: H204

    NASA has identified Nuclear Thermal Propulsion (NTP) as an approach that can provide the fastest trip times to Mars and as the preferred concept for human space travel. In order to perform component testing in support of NTP engine development, an efficient means for delivering high-flowrate, high-temperature hydrogen is required. Non-nuclear generation of the desired hydrogen flowrates and temper ...

    SBIR Phase II 2015 National Aeronautics and Space Administration
  10. Neuroimaging tools for presurgical brain mapping

    SBC: PRISM CLINICAL IMAGING, INC.            Topic: 102

    DESCRIPTION provided by applicant The goal of this project is to develop functional magnetic resonance imaging fMRI tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology The specific focus of this proposal is to produce a practical clinic ready suite of MR imaging methods analyses and display tools to solve the number one impediment to ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health

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