List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Engineered Living Bone Grafts for Complex Craniomaxillofacial Reconstructions

    SBC: EpiBone, Inc.            Topic: NIDCR

    DESCRIPTION provided by applicant EpiBone is a company engineering living anatomically precise and functionally mature bone grafts from autologous stem cells derived from fat aspirates Each year in the United States alone over bone reconstruction procedures are performed Facial fractures affecting the nasal area zygoma maxillary complex orbital area and mandible represent more t ...

    SBIR Phase II 2015 Department of Health and Human Services
  2. Multimodality Image-Based Assessment System for Traumatic Brain Injury

    SBC: Kitware, Inc.            Topic: 101

    DESCRIPTION provided by applicant Nearly million Americans suffer traumatic brain injury TBI annually which constitutes a significant US medical health concern Although neuroimaging plays an important role in pathology localization and surgical planning TBI clinical care does not currently take full advantage of neuroimaging computational technology We propose to develop validate a ...

    SBIR Phase II 2015 Department of Health and Human Services
  3. Identification of Biomarkers of Cardiotoxicity using Metabolomics of Human Pluripotent Stem Cell-Derived Cardiomyocytes

    SBC: STEMINA BIOMARKER DISCOVERY, INC            Topic: 300

    DESCRIPTION provided by applicant Identification of Biomarkers of Cardiotoxicity using Metabolomics of Human Pluripotent Stem Cell Derived Cardiomyocytes Project Summary Abstract Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of FDA approved drugs from the market The purpose of this proposal is to improve public health as well a ...

    SBIR Phase II 2015 Department of Health and Human Services
  4. Advanced virtual simulator for fundamentals of laparoscopic surgery training and credentialing

    SBC: Kitware, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant Surgical simulators are powerful tools that assist in providing advanced training for complex procedures and objective skills assessment They accelerate the training of residents without a penalty in morbidity and mortality while improving skills where patient outcome clearly correlates with surgical experience Fundamentals of laparoscopic surgery FLS is a ...

    SBIR Phase II 2015 Department of Health and Human Services
  5. Optical small animal imaging unit for quantification of bacterial infections

    SBC: IN VIVO ANALYTICS, INC.            Topic: NIBIB

    DESCRIPTION provided by applicant Bacterial infections impose a costly health burden worldwide which is compounded by the alarming increase of multi drug resistant bacteria Hence there is an urgent unmet need for developing new antibiotics with higher efficacy Bioluminescence imaging BLI is a tool for non invasively studying bacterial infections in small animal models aiding the developmen ...

    SBIR Phase II 2015 Department of Health and Human Services
  6. Engineered Tissue Based Phenotypic Screening of Mixture based Libraries

    SBC: INVIVOSCIENCES, INC.            Topic: NIA

    DESCRIPTION provided by applicant We propose to demonstrate the strength of combining our engineered tissue based drug screening approach and a systematically organized mixture based chemical library This approach could become an ultimate tool to develop treatments for complex diseases such as cardiac fibrosis without known drug targets initially Heart failure is the most common cause of ho ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. The Translational Development of a Therapeutic For Triple Negative Breast Cancer

    SBC: Nanometics LLC            Topic: 102

    DESCRIPTION provided by applicant Triple negative breast cancer TNBC accounts for of all diagnosed breast cancers worldwide TNBC carries a poorer prognosis and lower survival rate compared to other breast cancer subtypes Identifying novel targets and new therapeutics to treat patients diagnosed with TNBC remains a significant priority of the National Institutes of Health Product and ...

    SBIR Phase II 2015 Department of Health and Human Services
  8. Glycoconjugate therapeutic peptides for improved treatment of human diseases

    SBC: GLYCOBIA, INC.            Topic: 300

    DESCRIPTION provided by applicant Therapeutic peptides are used to treat human diseases ranging from HIV to diabetes and have some of the best features of small molecule and recombinant protein drugs Therapeutic peptides account for $ billion of annual pharmaceutical sales and are part of a growing sector of the biopharmaceutical market Unfortunately therapeutic peptides suffer from poor s ...

    SBIR Phase II 2015 Department of Health and Human Services
  9. Calibrated Methods for Quantitative PET/CT Imaging Phase II

    SBC: Kitware, Inc.            Topic: 102

    DESCRIPTION provided by applicant The overall goal of this Phase II STTR proposal is to develop a PET CT imaging tool that will help accelerate the development of effective cancer therapies by improving the utility of oncology trials using PET imaging The growing cost time and complexity of clinical trials are driving patient and pharmaceutical company demand for more objective efficient a ...

    STTR Phase II 2015 Department of Health and Human Services
  10. Platform for MR-Guided Neurotherapeutic Drug Delivery

    SBC: InseRT            Topic: 102

    DESCRIPTION provided by applicant Significance Accurate targeting guidance and monitoring of interventional therapy in the brain are critical for maximizing their effectiveness and safety during and following neurosurgical procedures Magnetic resonance imaging MRI is a critical tool for planning and guiding neurosurgical procedures In most cases the MRI is obtained during a pre operative ...

    SBIR Phase II 2015 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government