Award Data

DESCRIPTION provided by applicant Pulmokine is developing a novel inhaled PDGF receptor PDGFR kinase inhibitor PK as a treatment for Pulmonary Arterial Hypertension PAH The purpose of this Phase IIB Small Market Bridge Award is to progress PK through a phase A clinical trial for safety PAH is an orphan disease with high morbidity and mortality despite currently available treat ...

DESCRIPTION provided by applicant Autism spectrum disorder ASD is now diagnosed in of children with recent reports citing as many as in children in the United States The average age of diagnosis is more than years There is a need for a reliable biomarker based test for earlier diagnosis of ASD in young children to improve outcomes such as cognition social function and communic ...

DESCRIPTION provided by applicant NovelMed has developed an anti properdin antibody hNM for the treatment of intra and extravascular lysis in paroxysmal nocturnal hemoglobinuria PNH The selection of this antibody was based on positive results obtained from in vitro ex vivo in vivo and PK PD studies in rabbits and primates These strong positive results have provided a firm foundatio ...

ABSTRACT: A planned upgrade of the US nuclear arsenal will involve the replacement of aging arming and firing systems with FPGA and ASIC-based electronics. Due to the increased complexity of these electronics, a need exists for highly rigorous design verification that can be performed to assure the safety and reliability of these systems. The ECI solution consists of maintaining a well-documented ...

DESCRIPTION provided by applicant The global HIV AIDS epidemic continues to be fueled by the large number of individuals who do not know that they are infected The CDC is supporting programs to decrease this number by encouraging more frequent testing of all age groups as well as increasing the venues for testing including the recent FDA approval of an oral HIV Screening test for anti HIV anti ...

Man/hardware-in-the-loop laboratory simulation is the most cost-effective methodology for maturing advanced sensor technologies because the battlefield can be brought to the laboratory through multi-spectral synthetic battlespace simulation. Currentlaboratory simulation technologies cannot generate the real-time high fidelity dense RF environment required to advance space based and high altitude ...

Abstract The goal of this fast track SBIR proposal is to file an investigational new drugINDapplication for testing a novel anticancer drugFLthat is designed to overcome inherent and acquired treatment resistanceMany types of cancers are not detected until they are very advanced and have already become resistant to FDA approved treatmentsIn additionmany non advanced cancers respond well to initial ...

Future missile systems will abandon the traditional hemi-spherical shape for shapes resembling a tangent Ogive. An ogive shaped dome has better aerodynamic capabilities than its spherical counterpart. This enables the missile to fly faster, farther, and with more accuracy while also increasing its payload capacity. The optical material of choice is polycrystalline alumina, PCA, which is a hard cer ...

DESCRIPTION provided by applicant The objective is to engineer build and clinically validate DBS Expert an expert system for optimizing postoperative programming of deep brain stimulation DBS in patients with movement disorders such as Parkinsonandapos s disease PD The clinical utility of DBS for treatment of PD is well established However great outcome disparity exists among recipien ...

DESCRIPTION provided by applicant Translational studies are proposed to support the continued development of the JAA F antibody based therapy to address the critical need for a safe and effective treatment for metastatic breast cancer including triple negative breast cancers Building on the success of our Phase I project the overarching objectives of the Phase II application are to advanc ...